Thiram inhibits angiogenesis and slows the development of experimental tumours in mice.
Bottom Line: These effects were prevented by addition of antioxidants, indicating involvement of reactive oxygen species.These data indicate that the effects of thiram are mediated by inhibition of Cu/Zn superoxide dismutase activity.We found that oral administration of thiram (30 microg) to mice caused significant inhibition of C6 glioma tumour development (60%) and marked reduction (by 3-5-fold) in metastatic growth of Lewis lung carcinoma.
Affiliation: Department of Animal Sciences, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot 76100, Israel. firstname.lastname@example.orgShow MeSH
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Mentions: To further characterize the mechanism by which TR inhibits BCE cell growth, treated BCE cells were assayed for induction of apoptosis by the TUNEL method. BCE cells (40–50% confluence) that were incubated for 6 h with 1 μM of TR underwent apoptosis as evident by the positive TUNEL signals (Figure 5Figure 5
Affiliation: Department of Animal Sciences, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot 76100, Israel. email@example.com