Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo.
Bottom Line: Functional vessel density was markedly reduced on day 3 in treated animals compared to controls (37.2 +/- 12.1 vs 105.2 +/- 11.2 cm(-1); mean +/- s.e.m.; P<0.05) and increased subsequently in both groups.Inhibition of alpha(v)-integrins by a cyclic RGD-peptide resulted in significant reduction of functional vessel density, retardation of tumour growth and metastasis in vivo.Taken together, these results implicate RGD-peptides as agents which have anti-tumour and anti-metastatic activity in vivo.
Affiliation: Institute for Surgical Research, Klinikum Grosshadern, Marchioninistrasse 15, Ludwig-Maximilians-University, 81377 Munich, Germany.Show MeSH
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Mentions: Similar to vessel density, RBC velocity (vRBC) in tumour vessels of treated animals was markedly below values of controls on day 3 (0.026±0.01 vs 0.12±0.03 mm s−1; P<0.05; Figure 3Figure 3
Affiliation: Institute for Surgical Research, Klinikum Grosshadern, Marchioninistrasse 15, Ludwig-Maximilians-University, 81377 Munich, Germany.