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Reply: 99m Tc-labelled Stealth liposomal doxorubicin (Caelyx ® ) in glioblastomas and metastatic brain tumours

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ABSTRACT

86: British Journal of Cancer (2002) , 660–661. DOI: 10.1038/sj/bjc/6600094 www.bjcancer.com

© 2002 Cancer Research UK

No MeSH data available.


Comparison of images obtained from a patient with a large naso/parapharyngeal tumoural mass (white box marked on figures) using different radio-tracers (injection of 20 mCi, 20 min capture time): (A) 99mTc-sestamibi imaging at 2 h post-injection, (B) 99mTc-DTPA-Caelyx at 2 h post-injection, (C) 99mTc-DTPA at 1 h post-injection and (D) 99mTc-DTPA at 2 h post-injection.
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fig1: Comparison of images obtained from a patient with a large naso/parapharyngeal tumoural mass (white box marked on figures) using different radio-tracers (injection of 20 mCi, 20 min capture time): (A) 99mTc-sestamibi imaging at 2 h post-injection, (B) 99mTc-DTPA-Caelyx at 2 h post-injection, (C) 99mTc-DTPA at 1 h post-injection and (D) 99mTc-DTPA at 2 h post-injection.

Mentions: We believe that the best answer to whether our simple labelling technique labels Caelyx indeed, comes from the clinical practice. The patterns and quality of imaging using 99mTc-DTPA-Caelyx has been assessed in more than 30 non-small cell lung cancer patients comparatively with 99mTc-sestamibi (Koukourakis et al, 1997), while in five of them imaging with simple 99mTc-DTPA was also performed at 2 h post-injection. The patterns of normal tissue imaging using the three radio-pharmaceuticals was entirely different. The quality of tumour images obtained with sestamibi and labelled-Caelyx was very good, while in some cases liposomal imaging was even better. Tumour imaging with 99mTc-DTPA was of unacceptably poor quality, and rather absent in 3 out of 5 cases. Similar comparison of the three imaging procedures in patients with head and neck cancer showed an excellent imaging using labelled-Caelyx and 99mTc-sestamibi, while using 99mTc-DTPA the imaging was questionable especially at 2 h post-injection ( Figure 1Figure 1


Reply: 99m Tc-labelled Stealth liposomal doxorubicin (Caelyx ® ) in glioblastomas and metastatic brain tumours
Comparison of images obtained from a patient with a large naso/parapharyngeal tumoural mass (white box marked on figures) using different radio-tracers (injection of 20 mCi, 20 min capture time): (A) 99mTc-sestamibi imaging at 2 h post-injection, (B) 99mTc-DTPA-Caelyx at 2 h post-injection, (C) 99mTc-DTPA at 1 h post-injection and (D) 99mTc-DTPA at 2 h post-injection.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2375264&req=5

fig1: Comparison of images obtained from a patient with a large naso/parapharyngeal tumoural mass (white box marked on figures) using different radio-tracers (injection of 20 mCi, 20 min capture time): (A) 99mTc-sestamibi imaging at 2 h post-injection, (B) 99mTc-DTPA-Caelyx at 2 h post-injection, (C) 99mTc-DTPA at 1 h post-injection and (D) 99mTc-DTPA at 2 h post-injection.
Mentions: We believe that the best answer to whether our simple labelling technique labels Caelyx indeed, comes from the clinical practice. The patterns and quality of imaging using 99mTc-DTPA-Caelyx has been assessed in more than 30 non-small cell lung cancer patients comparatively with 99mTc-sestamibi (Koukourakis et al, 1997), while in five of them imaging with simple 99mTc-DTPA was also performed at 2 h post-injection. The patterns of normal tissue imaging using the three radio-pharmaceuticals was entirely different. The quality of tumour images obtained with sestamibi and labelled-Caelyx was very good, while in some cases liposomal imaging was even better. Tumour imaging with 99mTc-DTPA was of unacceptably poor quality, and rather absent in 3 out of 5 cases. Similar comparison of the three imaging procedures in patients with head and neck cancer showed an excellent imaging using labelled-Caelyx and 99mTc-sestamibi, while using 99mTc-DTPA the imaging was questionable especially at 2 h post-injection ( Figure 1Figure 1

View Article: PubMed Central

ABSTRACT

86: British Journal of Cancer (2002) , 660–661. DOI: 10.1038/sj/bjc/6600094 www.bjcancer.com

© 2002 Cancer Research UK

No MeSH data available.