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Prognostic impact of matched preoperative plasma and serum VEGF in patients with primary colorectal carcinoma.

Werther K, Christensen IJ, Nielsen HJ, Danish RANX05 Colorectal Cancer Study Gro - Br. J. Cancer (2002)

Bottom Line: In univariate survival analyses, both high plasma vascular endothelial growth factor (>112 pg ml(-1)) and high serum vascular endothelial growth factor (>533 pg ml(-1)) predicted a reduced survival.In multivariate survival analyses, high serum vascular endothelial growth factor (>533 pg ml(-1)) independently predicted a reduced survival (HR=1.65, P=0.015), while high plasma vascular endothelial growth factor (>112 pg ml(-1)) did not (HR=1.27, P=0.23).This study indicates that preoperative serum vascular endothelial growth factor apparently is a better predictor of overall survival than the preoperative plasma vascular endothelial growth factor.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Gastroenterology 435, Hvidovre University Hospital, University of Copenhagen, 2650 Hvidovre, Denmark. k.werther@ofir.dk

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(A) Percentile plot of preoperative plasma VEGF levels in the 524 colorectal cancer patients and in the 50 healthy volunteer blood donors. The upper 95-percentile limit of healthy volunteer blood donors (continuous line) is added to the figure. (B) Percentile plot of preoperative serum VEGF levels in the 524 colorectal cancer patients and in the 50 healthy volunteer blood donors. The upper 95-percentile limit of healthy volunteer blood donors (continuous line) is added to the figure.
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fig1: (A) Percentile plot of preoperative plasma VEGF levels in the 524 colorectal cancer patients and in the 50 healthy volunteer blood donors. The upper 95-percentile limit of healthy volunteer blood donors (continuous line) is added to the figure. (B) Percentile plot of preoperative serum VEGF levels in the 524 colorectal cancer patients and in the 50 healthy volunteer blood donors. The upper 95-percentile limit of healthy volunteer blood donors (continuous line) is added to the figure.

Mentions: In the 524 patients with CRC, the median plasma VEGF concentration was 44 pg ml−1 (range 0–1185). There was no significant correlation (rs=0.05, P=0.21) between age and plasma VEGF among the CRC patients, and no significant difference in plasma VEGF (P=0.32) between men and women. The percentile plot of the plasma VEGF measurements in the 524 CRC patients and in the 50 blood donors is shown in Figure 1AFigure 1


Prognostic impact of matched preoperative plasma and serum VEGF in patients with primary colorectal carcinoma.

Werther K, Christensen IJ, Nielsen HJ, Danish RANX05 Colorectal Cancer Study Gro - Br. J. Cancer (2002)

(A) Percentile plot of preoperative plasma VEGF levels in the 524 colorectal cancer patients and in the 50 healthy volunteer blood donors. The upper 95-percentile limit of healthy volunteer blood donors (continuous line) is added to the figure. (B) Percentile plot of preoperative serum VEGF levels in the 524 colorectal cancer patients and in the 50 healthy volunteer blood donors. The upper 95-percentile limit of healthy volunteer blood donors (continuous line) is added to the figure.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2375229&req=5

fig1: (A) Percentile plot of preoperative plasma VEGF levels in the 524 colorectal cancer patients and in the 50 healthy volunteer blood donors. The upper 95-percentile limit of healthy volunteer blood donors (continuous line) is added to the figure. (B) Percentile plot of preoperative serum VEGF levels in the 524 colorectal cancer patients and in the 50 healthy volunteer blood donors. The upper 95-percentile limit of healthy volunteer blood donors (continuous line) is added to the figure.
Mentions: In the 524 patients with CRC, the median plasma VEGF concentration was 44 pg ml−1 (range 0–1185). There was no significant correlation (rs=0.05, P=0.21) between age and plasma VEGF among the CRC patients, and no significant difference in plasma VEGF (P=0.32) between men and women. The percentile plot of the plasma VEGF measurements in the 524 CRC patients and in the 50 blood donors is shown in Figure 1AFigure 1

Bottom Line: In univariate survival analyses, both high plasma vascular endothelial growth factor (>112 pg ml(-1)) and high serum vascular endothelial growth factor (>533 pg ml(-1)) predicted a reduced survival.In multivariate survival analyses, high serum vascular endothelial growth factor (>533 pg ml(-1)) independently predicted a reduced survival (HR=1.65, P=0.015), while high plasma vascular endothelial growth factor (>112 pg ml(-1)) did not (HR=1.27, P=0.23).This study indicates that preoperative serum vascular endothelial growth factor apparently is a better predictor of overall survival than the preoperative plasma vascular endothelial growth factor.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Gastroenterology 435, Hvidovre University Hospital, University of Copenhagen, 2650 Hvidovre, Denmark. k.werther@ofir.dk

Show MeSH
Related in: MedlinePlus