Mitomycin C in combination with radiotherapy as a potent inhibitor of tumour cell repopulation in a human squamous cell carcinoma.
Bottom Line: Graded top up doses (clamped blood flow: 0-57 Gy) were given at day 16, 23, 30 or 37.End point of the study was the time to local tumour progression.Mitomycin C decreased the relative risk of local recurrence by 94% (P<0.001) equivalent to 31.7 Gy top up dose.
Affiliation: Department of Radiation Oncology, University of Tuebingen, Hoppe-Seyler-Str. 3, D-72076 Tuebingen, Germany. email@example.comShow MeSH
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Mentions: A total of 256 animals received fractionated radiotherapy±MMC with or without top up irradiation. Locally recurrent tumours were observed in 84 out of 117 animals (71.8%) in the radiotherapy alone arm (all top up days) and in 44 out of 139 animals (31.7%) in the radiotherapy+MMC arm (all top up days) of the study (P<0.001), although the median top up doses were 15 Gy lower in the MMC arm (30 Gy vs 15 Gy) (Figure 4Figure 4
Affiliation: Department of Radiation Oncology, University of Tuebingen, Hoppe-Seyler-Str. 3, D-72076 Tuebingen, Germany. firstname.lastname@example.org