Muscle UCP-3 mRNA levels are elevated in weight loss associated with gastrointestinal adenocarcinoma in humans.
Bottom Line: The mitochondrial uncoupling proteins-2 and -3 are putative mediators of thermogenesis and energy expenditure.Uncoupling proteins-2 mRNA levels did not differ significantly between groups.Elevations in muscle uncoupling proteins-3 activity may enhance energy expenditure and this in turn could contribute to tissue catabolism.
Affiliation: Gastroenterology Unit, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK. firstname.lastname@example.orgShow MeSH
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Mentions: Table 2Table 2UCP-2 and -3 mRNA expression for each of the studied groups. Data is expressed as a ratio: optical density (OD) UCP-2 or -3 to OD of HPRT shows the levels of UCP-2 and -3 mRNA, expressed as ratios to HPRT mRNA; these data are expressed graphically in Figure 1Figure 1
Affiliation: Gastroenterology Unit, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK. email@example.com