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Occult axillary lymph node metastases are of no prognostic significance in breast cancer.

Millis RR, Springall R, Lee AH, Ryder K, Rytina ER, Fentiman IS - Br. J. Cancer (2002)

Bottom Line: The median follow-up was 18.9 years with 153 breast cancer related deaths.Multivariate analysis, however, showed that survival was related to tumour size and histological grade.We believe that the current evidence does not support the routine use of serial sections or immunohistochemistry for the detection of occult metastases in the management of lymph node negative patients, but that the traditional factors of histological grade and tumour size are useful.

View Article: PubMed Central - PubMed

Affiliation: Hedley Atkins ICRF Breast Pathology Laboratory, Guy's Hospital, London SE1 9RT, UK.

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Overall survival of axillary node negative patients with and without occult metastases, and of patients with a single involved axillary node. There was no difference between node negative patients with and without occult metastases χ2=1.9, P=0.17. Survival was worse in patients with a single involved axillary node compared with the node negative group χ2=32.7, P<0.0001, and compared with the node negative patients with occult metastases χ2=4.1, P=0.04. The table underneath shows patients at risk at 5-yearly intervals.
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fig1: Overall survival of axillary node negative patients with and without occult metastases, and of patients with a single involved axillary node. There was no difference between node negative patients with and without occult metastases χ2=1.9, P=0.17. Survival was worse in patients with a single involved axillary node compared with the node negative group χ2=32.7, P<0.0001, and compared with the node negative patients with occult metastases χ2=4.1, P=0.04. The table underneath shows patients at risk at 5-yearly intervals.

Mentions: Overall survival (Figure 1Figure 1


Occult axillary lymph node metastases are of no prognostic significance in breast cancer.

Millis RR, Springall R, Lee AH, Ryder K, Rytina ER, Fentiman IS - Br. J. Cancer (2002)

Overall survival of axillary node negative patients with and without occult metastases, and of patients with a single involved axillary node. There was no difference between node negative patients with and without occult metastases χ2=1.9, P=0.17. Survival was worse in patients with a single involved axillary node compared with the node negative group χ2=32.7, P<0.0001, and compared with the node negative patients with occult metastases χ2=4.1, P=0.04. The table underneath shows patients at risk at 5-yearly intervals.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2375207&req=5

fig1: Overall survival of axillary node negative patients with and without occult metastases, and of patients with a single involved axillary node. There was no difference between node negative patients with and without occult metastases χ2=1.9, P=0.17. Survival was worse in patients with a single involved axillary node compared with the node negative group χ2=32.7, P<0.0001, and compared with the node negative patients with occult metastases χ2=4.1, P=0.04. The table underneath shows patients at risk at 5-yearly intervals.
Mentions: Overall survival (Figure 1Figure 1

Bottom Line: The median follow-up was 18.9 years with 153 breast cancer related deaths.Multivariate analysis, however, showed that survival was related to tumour size and histological grade.We believe that the current evidence does not support the routine use of serial sections or immunohistochemistry for the detection of occult metastases in the management of lymph node negative patients, but that the traditional factors of histological grade and tumour size are useful.

View Article: PubMed Central - PubMed

Affiliation: Hedley Atkins ICRF Breast Pathology Laboratory, Guy's Hospital, London SE1 9RT, UK.

Show MeSH
Related in: MedlinePlus