E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia.
Bottom Line: Expression of p73 in normal cervical epithelium is confined to the basal and supra-basal layers.In contrast, expression in neoplastic lesions is detected throughout the epithelium and increases with grade of neoplasia, being maximal in squamous cell cancers (SCC).The frequent over-expression of p73Delta2, which has recognized transdominant properties, in malignant and pre-malignant lesions suggests a role in the oncogenic process in cervical epithelium.
Affiliation: Ludwig Institute for Cancer Research, St Mary's Hospital Medical School, Norfolk Place, London W2 1PG, UK.Show MeSH
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Mentions: To address the relevance of the results obtained from transient assays and cell lines, we performed RTâ€“PCR and immunocytochemical analysis of p73 expression in primary cervical tissues, these comprising a series of HPV 16 positive CIN I, CIN III and cervical SCC (Figures 3Figure 3
Affiliation: Ludwig Institute for Cancer Research, St Mary's Hospital Medical School, Norfolk Place, London W2 1PG, UK.