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Expression of oestrogen receptor beta (ERbeta1) protein in human breast cancer biopsies.

Saunders PT, Millar MR, Williams K, Macpherson S, Bayne C, O'Sullivan C, Anderson TJ, Groome NP, Miller WR - Br. J. Cancer (2002)

Bottom Line: Western blot analysis of breast tumours contained both forms of oestrogen receptor beta protein although in some samples lower molecular weight species (32--45 Kd) were identified.Expression of oestrogen receptor beta was exclusively nuclear and occurred in multiple cell types.There was no quantitative relationship between staining for the two ERs although in tumours in which both receptors were present immunoexpression of oestrogen receptor alpha was invariably more intense.

View Article: PubMed Central - PubMed

Affiliation: MRC Human Reproductive Sciences Unit, 37 Chalmers Street, Edinburgh, EH3 9ET, UK. p.saunders@ed.ac.uk

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Immunoexpression of ERα in human breast cancers. Nuclear expression of ERα was largely confined to malignant epithelium in the 40 samples in which it was detected; intensity was variable. (A) example of intense immunostaining (sample code 5580); (B) sample code 5667, magnification ×20, insets A′ and B′ show higher power magnification of the same tissue samples.
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fig3: Immunoexpression of ERα in human breast cancers. Nuclear expression of ERα was largely confined to malignant epithelium in the 40 samples in which it was detected; intensity was variable. (A) example of intense immunostaining (sample code 5580); (B) sample code 5667, magnification ×20, insets A′ and B′ show higher power magnification of the same tissue samples.

Mentions: Typical examples of immunostaining for ERα and ERβ are shown in Figures 3Figure 3


Expression of oestrogen receptor beta (ERbeta1) protein in human breast cancer biopsies.

Saunders PT, Millar MR, Williams K, Macpherson S, Bayne C, O'Sullivan C, Anderson TJ, Groome NP, Miller WR - Br. J. Cancer (2002)

Immunoexpression of ERα in human breast cancers. Nuclear expression of ERα was largely confined to malignant epithelium in the 40 samples in which it was detected; intensity was variable. (A) example of intense immunostaining (sample code 5580); (B) sample code 5667, magnification ×20, insets A′ and B′ show higher power magnification of the same tissue samples.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2375186&req=5

fig3: Immunoexpression of ERα in human breast cancers. Nuclear expression of ERα was largely confined to malignant epithelium in the 40 samples in which it was detected; intensity was variable. (A) example of intense immunostaining (sample code 5580); (B) sample code 5667, magnification ×20, insets A′ and B′ show higher power magnification of the same tissue samples.
Mentions: Typical examples of immunostaining for ERα and ERβ are shown in Figures 3Figure 3

Bottom Line: Western blot analysis of breast tumours contained both forms of oestrogen receptor beta protein although in some samples lower molecular weight species (32--45 Kd) were identified.Expression of oestrogen receptor beta was exclusively nuclear and occurred in multiple cell types.There was no quantitative relationship between staining for the two ERs although in tumours in which both receptors were present immunoexpression of oestrogen receptor alpha was invariably more intense.

View Article: PubMed Central - PubMed

Affiliation: MRC Human Reproductive Sciences Unit, 37 Chalmers Street, Edinburgh, EH3 9ET, UK. p.saunders@ed.ac.uk

Show MeSH
Related in: MedlinePlus