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Prognostic significance of dihydropyrimidine dehydrogenase expression in breast cancer.

Horiguchi J, Takei H, Koibuchi Y, Iijima K, Ninomiya J, Uchida K, Ochiai R, Yoshida M, Yokoe T, Iino Y, Morishita Y - Br. J. Cancer (2002)

Bottom Line: When evaluated in patients treated with 5-fluorouracil or 5-fluorouracil derivatives, patients with dihydropyrimidine dehydrogenase-positive tumours had a significantly (P<0.05) poorer disease-free survival compared to those with dihydropyrimidine dehydrogenase-negative tumour.No conclusion can be drawn about the prognostic impact of dihydropyrimidine dehydrogenase status in patients who were not treated with 5-fluorouracil regimes due to the small number of such cases in this series.In conclusion, dihydropyrimidine dehydrogenase is a possible prognostic factor in patients with breast cancer treated with 5-fluorouracil or 5-fluorouracil derivatives.

View Article: PubMed Central - PubMed

Affiliation: Second Department of Surgery, Gunma University Faculty of Medicine, Showa-machi 3-39-15, Maebashi, Gunma 371-8511, Japan. junhorig@showa.gunma-u.ac.uk

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Disease-free survival by DPD expression in patients treated with 5-FU or 5-FU derivatives. Patients with DPD-positive tumour had significantly (P<0.05) poorer disease-free survival than those with DPD-negative tumour in patients treated with 5-FU or 5-FU derivatives.
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fig4: Disease-free survival by DPD expression in patients treated with 5-FU or 5-FU derivatives. Patients with DPD-positive tumour had significantly (P<0.05) poorer disease-free survival than those with DPD-negative tumour in patients treated with 5-FU or 5-FU derivatives.

Mentions: Overall survival by DPD expression. Patients with DPD-positive tumour had a significantly (P<0.05) poorer overall survival than those with DPD-negative tumour.


Prognostic significance of dihydropyrimidine dehydrogenase expression in breast cancer.

Horiguchi J, Takei H, Koibuchi Y, Iijima K, Ninomiya J, Uchida K, Ochiai R, Yoshida M, Yokoe T, Iino Y, Morishita Y - Br. J. Cancer (2002)

Disease-free survival by DPD expression in patients treated with 5-FU or 5-FU derivatives. Patients with DPD-positive tumour had significantly (P<0.05) poorer disease-free survival than those with DPD-negative tumour in patients treated with 5-FU or 5-FU derivatives.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2375185&req=5

fig4: Disease-free survival by DPD expression in patients treated with 5-FU or 5-FU derivatives. Patients with DPD-positive tumour had significantly (P<0.05) poorer disease-free survival than those with DPD-negative tumour in patients treated with 5-FU or 5-FU derivatives.
Mentions: Overall survival by DPD expression. Patients with DPD-positive tumour had a significantly (P<0.05) poorer overall survival than those with DPD-negative tumour.

Bottom Line: When evaluated in patients treated with 5-fluorouracil or 5-fluorouracil derivatives, patients with dihydropyrimidine dehydrogenase-positive tumours had a significantly (P<0.05) poorer disease-free survival compared to those with dihydropyrimidine dehydrogenase-negative tumour.No conclusion can be drawn about the prognostic impact of dihydropyrimidine dehydrogenase status in patients who were not treated with 5-fluorouracil regimes due to the small number of such cases in this series.In conclusion, dihydropyrimidine dehydrogenase is a possible prognostic factor in patients with breast cancer treated with 5-fluorouracil or 5-fluorouracil derivatives.

View Article: PubMed Central - PubMed

Affiliation: Second Department of Surgery, Gunma University Faculty of Medicine, Showa-machi 3-39-15, Maebashi, Gunma 371-8511, Japan. junhorig@showa.gunma-u.ac.uk

Show MeSH
Related in: MedlinePlus