Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin.
Bottom Line: Systemic side-effects were very low (grade I WHO) in both groups.Side-effects were found to be similar to post-embolization syndrome (swelling, mild to moderate pain, leucocytosis without fever) in the study group.Chemoembolization in the head and neck area can be carried out routinely using this method.
Affiliation: Clinic for Maxillofacial Plastic Surgery, Johann Wolfgang Goethe-University Medical School, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. A.Kovacs@em.uni-frankfurt.deShow MeSH
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Mentions: At the day of intervention the patients received 74 mg dolasetron and 500 mg prednisolone i.v. (between 0700 and 0800 h Greenwich Mean Time, GMT). A 1.5 l dose of a full electrolyte solution (with 20 mval potassium chloride) was administered subsequently by i.v. infusion over 2 h. Transcutaneous catheterization of the right femoral artery was carried out subsequently using a 4-french catheter containing a coaxial micro-catheter. Superselective visualization of the tumour-feeding vessel and assessment of its volume capacity using fluoroscopy and a contrast medium were performed. It never has been necessary to perform a provocation test because angiography in these areas usually reveals enough information. Then, 150 mg m−2 cisplatin (maximal absolute dose 300 mg, lowest dose 225 mg) suspended as mentioned above (maximal amount of fluid: 60 ml, smallest amount 45 ml) was infused with controlled pressure via a hand-held syringe. In all cases, stasis of flow inside the peripheral capillaries of the tumour could be noticed via fluoroscopy (Figures 3Figure 3
Affiliation: Clinic for Maxillofacial Plastic Surgery, Johann Wolfgang Goethe-University Medical School, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. A.Kovacs@em.uni-frankfurt.de