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Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin.

Kovács AF, Obitz P, Wagner M - Br. J. Cancer (2002)

Bottom Line: Systemic side-effects were very low (grade I WHO) in both groups.Side-effects were found to be similar to post-embolization syndrome (swelling, mild to moderate pain, leucocytosis without fever) in the study group.Chemoembolization in the head and neck area can be carried out routinely using this method.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Maxillofacial Plastic Surgery, Johann Wolfgang Goethe-University Medical School, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. A.Kovacs@em.uni-frankfurt.de

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Backlit photography of a drop (12×7 mm) of the aqueous cisplatin suspension on a slide showing the larger crystalline particles.
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fig1: Backlit photography of a drop (12×7 mm) of the aqueous cisplatin suspension on a slide showing the larger crystalline particles.

Mentions: The preparation method results in a monocomponent, a highly concentrated aqueous suspension of cisplatin with precipitation of crystals. The physicochemical properties (e.g.: Pt…Pt distances, molecular vibration analyses) of cisplatin crystals which did form in frozen solutions have been previously described elsewhere (Milburn and Truter, 1966). The stability of the cisplatin complex is pharmacologically assured in a suspension because sodium chloride is solved in a high concentration in this dosage format. The resulting fluid is a 5.4% sodium chloride solution. Hypertonic sodium chloride solutions reportedly do not have effect on pharmacokinetics of cisplatin (medac, 2000). The osmolality is supposedly higher than in an aqueous solution (about 285 mOsm kg−1 (McEvoy, 1991)) but cannot be measured exactly because of the presence of crystalline precipitates. Theoretic osmolality of the described suspension as calculated approximately is 2130 mOsm kg−1. Microscopic assessment of particle diameters in the aqueous crystal suspension of cisplatin showed rod-shaped crystals measuring 3×8 μm; regular clumping of these crystals formed particles measuring 30×50 μm (Figures 1Figure 1


Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin.

Kovács AF, Obitz P, Wagner M - Br. J. Cancer (2002)

Backlit photography of a drop (12×7 mm) of the aqueous cisplatin suspension on a slide showing the larger crystalline particles.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2375182&req=5

fig1: Backlit photography of a drop (12×7 mm) of the aqueous cisplatin suspension on a slide showing the larger crystalline particles.
Mentions: The preparation method results in a monocomponent, a highly concentrated aqueous suspension of cisplatin with precipitation of crystals. The physicochemical properties (e.g.: Pt…Pt distances, molecular vibration analyses) of cisplatin crystals which did form in frozen solutions have been previously described elsewhere (Milburn and Truter, 1966). The stability of the cisplatin complex is pharmacologically assured in a suspension because sodium chloride is solved in a high concentration in this dosage format. The resulting fluid is a 5.4% sodium chloride solution. Hypertonic sodium chloride solutions reportedly do not have effect on pharmacokinetics of cisplatin (medac, 2000). The osmolality is supposedly higher than in an aqueous solution (about 285 mOsm kg−1 (McEvoy, 1991)) but cannot be measured exactly because of the presence of crystalline precipitates. Theoretic osmolality of the described suspension as calculated approximately is 2130 mOsm kg−1. Microscopic assessment of particle diameters in the aqueous crystal suspension of cisplatin showed rod-shaped crystals measuring 3×8 μm; regular clumping of these crystals formed particles measuring 30×50 μm (Figures 1Figure 1

Bottom Line: Systemic side-effects were very low (grade I WHO) in both groups.Side-effects were found to be similar to post-embolization syndrome (swelling, mild to moderate pain, leucocytosis without fever) in the study group.Chemoembolization in the head and neck area can be carried out routinely using this method.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Maxillofacial Plastic Surgery, Johann Wolfgang Goethe-University Medical School, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. A.Kovacs@em.uni-frankfurt.de

Show MeSH
Related in: MedlinePlus