Variants of the long control region and the E6 oncogene in European human papillomavirus type 16 isolates: implications for cervical disease.
Bottom Line: This could partially explain why some lesions progress to cancer while others do not.In addition, we found a specific European E6 variant, L83V, to be enriched in high-grade lesions and cancer rather than a specific European long control region variant.The difference in oncogenicity between European HPV16 genotypes is more probably due to an altered property of the corresponding E6 proteins rather than to an altered activity of the P97 promoter.
Affiliation: Institute of Virology, University of Cologne, Fürst-Pückler-Strasse 56, D-50935 Cologne, Germany.Show MeSH
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Mentions: After PCR, the entire HPV16 LCR (nts 7010–124) and the entire HPV16 E6 gene (nts 83–559) were sequenced and compared with the European reference sequence (HPV16R sequence in the HPV database). The sequences of all samples tested in the present investigation are summarized in Figure 1Figure 1
Affiliation: Institute of Virology, University of Cologne, Fürst-Pückler-Strasse 56, D-50935 Cologne, Germany.