Recovery of zeta-chain expression and changes in spontaneous IL-10 production after PSA-based vaccines in patients with prostate cancer.
Bottom Line: Prior to therapy, the patients were found to have significantly lower zeta-chain expression in circulating CD3(+) cells and a higher percentage of zeta-chain negative CD3(+) and CD4(+) cells than normal donors.Only one of 18 patients was a clinical responder.The vaccine had stimulatory effects on the patients' immune system, but post-vaccine immune recovery could not be correlated to progression-free survival in this small cohort of patients with prostate cancer.
Affiliation: University of Pittsburgh Cancer Institute, W1041 Biomedical Science Tower, 211 Lothrop Street, Pittsburgh, Pennsylvania, PA 15213-2582, USA.Show MeSH
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Mentions: In addition, cells of all six donors were repeatedly obtained at three time points separated by 1 month, and at each time point were tested together in one assay in order to determine biologic (intra-individual) variability in ζ-chain expression (Figure 1Figure 1
Affiliation: University of Pittsburgh Cancer Institute, W1041 Biomedical Science Tower, 211 Lothrop Street, Pittsburgh, Pennsylvania, PA 15213-2582, USA.