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Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas.

Passalidou E, Trivella M, Singh N, Ferguson M, Hu J, Cesario A, Granone P, Nicholson AG, Goldstraw P, Ratcliffe C, Tetlow M, Leigh I, Harris AL, Gatter KC, Pezzella F - Br. J. Cancer (2002)

Bottom Line: In the nine putative non-angiogenic cases examined, the vascular phenotype of all the vessels was the same as that of alveolar vessels in normal lung: LH39 positive and alphaVbeta3 variable or negative.Instead in 104 angiogenic tumours examined, only a minority of vessels (mean 13.1%; range 0--60%) expressed LH39, while alphaVbeta3 (in 45 cases) was strongly expressed on many vessels (mean 55.5%; range 5--90%).We conclude that in putative non-angiogenic tumours the vascular phenotype is that of normal vessels and there is no neo-angiogenesis.

View Article: PubMed Central - PubMed

Affiliation: 3rd Department of Respiratory Medicine, Sismanogleiou Hospital, Sismanogleiou 1, PC 15126 Athens, Greece.

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Related in: MedlinePlus

Phenotype of intratumour vessels in 44 angiogenic lung n-SCLC. Three groups of tumours can be identified. Groups A (diamonds) and B (triangles) are made up of a mixture of mature (LH39 positive) and immature (LH39 negative) vessels. However while in group A all the immature express αVβ3, in group B the immature are, in part, αVβ3 negative. Group C (circles) is made up almost completely by new vessels (LH39 negative) but only a proportion are αVβ3 positive. N.B.: each symbol in the diagram may well represent more than one sample.
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fig4: Phenotype of intratumour vessels in 44 angiogenic lung n-SCLC. Three groups of tumours can be identified. Groups A (diamonds) and B (triangles) are made up of a mixture of mature (LH39 positive) and immature (LH39 negative) vessels. However while in group A all the immature express αVβ3, in group B the immature are, in part, αVβ3 negative. Group C (circles) is made up almost completely by new vessels (LH39 negative) but only a proportion are αVβ3 positive. N.B.: each symbol in the diagram may well represent more than one sample.

Mentions: An angiogenic lung carcinoma (frozen sections). (A) (×400) double immunostaining for LH39 (in brown) and CD31 (in blue) no counter staining was done. Only a few vessels express LH39 in the basal membrane. (B) (×400) Immunostaining for αVβ3 (in brown). The nuclei are counter stained with haematoxilin (blue). Some vessels are strongly stained.


Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas.

Passalidou E, Trivella M, Singh N, Ferguson M, Hu J, Cesario A, Granone P, Nicholson AG, Goldstraw P, Ratcliffe C, Tetlow M, Leigh I, Harris AL, Gatter KC, Pezzella F - Br. J. Cancer (2002)

Phenotype of intratumour vessels in 44 angiogenic lung n-SCLC. Three groups of tumours can be identified. Groups A (diamonds) and B (triangles) are made up of a mixture of mature (LH39 positive) and immature (LH39 negative) vessels. However while in group A all the immature express αVβ3, in group B the immature are, in part, αVβ3 negative. Group C (circles) is made up almost completely by new vessels (LH39 negative) but only a proportion are αVβ3 positive. N.B.: each symbol in the diagram may well represent more than one sample.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2375177&req=5

fig4: Phenotype of intratumour vessels in 44 angiogenic lung n-SCLC. Three groups of tumours can be identified. Groups A (diamonds) and B (triangles) are made up of a mixture of mature (LH39 positive) and immature (LH39 negative) vessels. However while in group A all the immature express αVβ3, in group B the immature are, in part, αVβ3 negative. Group C (circles) is made up almost completely by new vessels (LH39 negative) but only a proportion are αVβ3 positive. N.B.: each symbol in the diagram may well represent more than one sample.
Mentions: An angiogenic lung carcinoma (frozen sections). (A) (×400) double immunostaining for LH39 (in brown) and CD31 (in blue) no counter staining was done. Only a few vessels express LH39 in the basal membrane. (B) (×400) Immunostaining for αVβ3 (in brown). The nuclei are counter stained with haematoxilin (blue). Some vessels are strongly stained.

Bottom Line: In the nine putative non-angiogenic cases examined, the vascular phenotype of all the vessels was the same as that of alveolar vessels in normal lung: LH39 positive and alphaVbeta3 variable or negative.Instead in 104 angiogenic tumours examined, only a minority of vessels (mean 13.1%; range 0--60%) expressed LH39, while alphaVbeta3 (in 45 cases) was strongly expressed on many vessels (mean 55.5%; range 5--90%).We conclude that in putative non-angiogenic tumours the vascular phenotype is that of normal vessels and there is no neo-angiogenesis.

View Article: PubMed Central - PubMed

Affiliation: 3rd Department of Respiratory Medicine, Sismanogleiou Hospital, Sismanogleiou 1, PC 15126 Athens, Greece.

Show MeSH
Related in: MedlinePlus