The free beta-subunit of human chorionic gonadotropin as a prognostic factor in renal cell carcinoma.
Bottom Line: The free beta-subunit of human chorionic gonadotropin beta is expressed in several nontrophoblastic tumours and this is usually associated with aggressive disease.The concentrations did not correlate with clinical stage and histopathological grade, but patients with increased human chorionic gonadotropin beta levels had significantly shorter survival time than those with levels below the median (cut-off 1.2 pmol l(-1), P=0.0029).The preoperative value of human chorionic gonadotropin beta in serum may be used to identify patents with increased risk of progressive disease.
Affiliation: Department of Clinical Chemistry, Helsinki University Central Hospital, Biomedicum Helsinki, Rm A418a Haartmaninkatu 8, FIN-00029, Helsinki, Finland. firstname.lastname@example.orgShow MeSH
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Mentions: The concentration of hCGβ in serum was elevated (>2 pmol l−1) in 23% of the patients with RCC (Table 2Table 2Fraction of elevated serum hCGβ concentration in relation to stage) and 20 of these (11%) had values >4 pmol l−1. The median concentration of hCGβ in serum was 1.2 pmol l−1 (range 0.2–18 pmol l−1), which was significantly higher (P<0.0001) than in controls (median 0.4 pmol l−1, range 0.2–1.3 pmol l−1). There was no difference in hCGβ levels between males and females, different age groups, different RCC types, aneuploid and diploid tumours, or tumours with and without venous invasion. Serum hCGβ concentrations were not either significantly correlated with tumour stage or grade (Figure 1Figure 1
Affiliation: Department of Clinical Chemistry, Helsinki University Central Hospital, Biomedicum Helsinki, Rm A418a Haartmaninkatu 8, FIN-00029, Helsinki, Finland. email@example.com