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Radiation-Induced Leiomyosarcoma after Breast Cancer Treatment and TRAM Flap Reconstruction.

Olcina M, Merck B, Giménez-Climent MJ, Almenar S, Sancho-Merle MF, Llopis F, Vázquez-Albadalejo C - Sarcoma (2008)

Bottom Line: Its frequency is rising in relation with increasing survival of breast cancer patients treated with adjuvant radiation therapy, and is associated with poor prognosis despite treatment.A delayed TRAM flap reconstruction was performed 10 years after and a rapid growing mass under the reconstructed flap appeared, on routine follow-up, twenty years later.This report analyzes the diagnostic and therapeutic approach of patients with RIS.

View Article: PubMed Central - PubMed

Affiliation: Surgery Department, Hospital General de Alicante, 03010 Alicante, Spain.

ABSTRACT
The development of a radiation-induced sarcoma (RIS) in the post mastectomy thoracic treatment volume is an infrequent, but recognized, event. Its frequency is rising in relation with increasing survival of breast cancer patients treated with adjuvant radiation therapy, and is associated with poor prognosis despite treatment. We present a case of leiomyosarcoma in a patient who underwent mastectomy followed by radiotherapy for invasive ductal carcinoma. A delayed TRAM flap reconstruction was performed 10 years after and a rapid growing mass under the reconstructed flap appeared, on routine follow-up, twenty years later. This report analyzes the diagnostic and therapeutic approach of patients with RIS.

No MeSH data available.


Related in: MedlinePlus

(a) MRI: tumor growth on right breast area. (b) MRI: myocutaneous flap infiltration.
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fig1: (a) MRI: tumor growth on right breast area. (b) MRI: myocutaneous flap infiltration.

Mentions: Magnetic resonance imaging revealed a tumor (13 × 16 × 10 centimetres)located on the right breast area, infiltrating to a large extent themyocutaneous flap and the adjacent costal wall, mostly on the inferior border(Figures 1(a) and 1(b)). The biopsy demonstrated a tumor composed of fasciclesof elongated spindle-shaped cells with eosinophilic cytoplasm and blunt-ended(cigar-shaped) nuclei. Some pleomorphic, multilobulated malignant cells werereported. Immunohistochemical staining showed similar cellular features and thepresence of smooth muscle actin in the cytoplasm (Figures 2(a) and 2(b)).


Radiation-Induced Leiomyosarcoma after Breast Cancer Treatment and TRAM Flap Reconstruction.

Olcina M, Merck B, Giménez-Climent MJ, Almenar S, Sancho-Merle MF, Llopis F, Vázquez-Albadalejo C - Sarcoma (2008)

(a) MRI: tumor growth on right breast area. (b) MRI: myocutaneous flap infiltration.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2366071&req=5

fig1: (a) MRI: tumor growth on right breast area. (b) MRI: myocutaneous flap infiltration.
Mentions: Magnetic resonance imaging revealed a tumor (13 × 16 × 10 centimetres)located on the right breast area, infiltrating to a large extent themyocutaneous flap and the adjacent costal wall, mostly on the inferior border(Figures 1(a) and 1(b)). The biopsy demonstrated a tumor composed of fasciclesof elongated spindle-shaped cells with eosinophilic cytoplasm and blunt-ended(cigar-shaped) nuclei. Some pleomorphic, multilobulated malignant cells werereported. Immunohistochemical staining showed similar cellular features and thepresence of smooth muscle actin in the cytoplasm (Figures 2(a) and 2(b)).

Bottom Line: Its frequency is rising in relation with increasing survival of breast cancer patients treated with adjuvant radiation therapy, and is associated with poor prognosis despite treatment.A delayed TRAM flap reconstruction was performed 10 years after and a rapid growing mass under the reconstructed flap appeared, on routine follow-up, twenty years later.This report analyzes the diagnostic and therapeutic approach of patients with RIS.

View Article: PubMed Central - PubMed

Affiliation: Surgery Department, Hospital General de Alicante, 03010 Alicante, Spain.

ABSTRACT
The development of a radiation-induced sarcoma (RIS) in the post mastectomy thoracic treatment volume is an infrequent, but recognized, event. Its frequency is rising in relation with increasing survival of breast cancer patients treated with adjuvant radiation therapy, and is associated with poor prognosis despite treatment. We present a case of leiomyosarcoma in a patient who underwent mastectomy followed by radiotherapy for invasive ductal carcinoma. A delayed TRAM flap reconstruction was performed 10 years after and a rapid growing mass under the reconstructed flap appeared, on routine follow-up, twenty years later. This report analyzes the diagnostic and therapeutic approach of patients with RIS.

No MeSH data available.


Related in: MedlinePlus