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A middle-aged female with recurrent sinopulmonary infections: a case report.

Yalavarthy UC, Panda M - J Med Case Rep (2008)

Bottom Line: Physical examination was significant for bibasilar rhonchi.Laboratory data were significant for leukocytosis of 15,700/mm3.Although intravenous immunoglobulin provides improvement in these patients, early diagnosis is the key to preventing significant morbidity and mortality and improving prognosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine, University of Tennessee, College of Medicine-Chattanooga, Chattanooga, USA. umesheras@yahoo.ca

ABSTRACT

Introduction: Common variable immunodeficiency (CVID) is a form of severe antibody deficiency with an estimated prevalence of 1 in 25,000 to 1 in 100,000. The disorder apparently results from currently undefined immune deregulations resulting in failed B-cell differentiation with impaired secretion of immunoglobulins. It has a broad range of clinical symptoms including recurrent infections of the respiratory tract, chronic lung disease, autoimmune diseases, liver and gastrointestinal disorders, granulomatous infiltrations, lymphoma and solid tumors.

Case presentation: A 42-year-old Caucasian female presented with a one-day history of high-grade fever and productive cough associated with retrosternal chest pain. The patient had been discharged one week prior after a prolonged stay in an intensive care unit with multiorgan failure requiring temporary hemodialysis for two weeks secondary to sepsis. Past medical history was significant for chronic obstructive pulmonary disease, recurrent pneumonias and recurrent sinus infections since adolescence. She had a temperature of 99.8 degrees F, was tachycardic (137/min), tachypneic (26/min) with a blood pressure of 109/59 mmHg and oxygen saturation of 88% on 2 l/min nasal oxygen. Physical examination was significant for bibasilar rhonchi. Laboratory data were significant for leukocytosis of 15,700/mm3. Chest X-ray demonstrated bibasilar infiltrates. The patient was started on intravenous levofloxacin and vancomycin, and sputum gram stain and cultures were performed. Given the patient's recurrent respiratory infections, an underlying immunologic disorder was considered. Work-up revealed immunoglobulin A (IgA) 11 mg/dl (normal 70-400 mg/dl), immunoglobulin M (IgM) 2 mg/dl (normal 40-230 mg/dl) and IgG 53 mg/dl (normal 700-1,600 mg/dl). The patient was diagnosed with CVID and started on intravenous immunoglobulin. She was initially started on a four-week regimen of intravenous immunoglobulin, which was later switched to a three-week regimen as the patient had respiratory infections on the four-week regimen. She remained asymptomatic on a three times/week intravenous immunoglobulin regimen.

Conclusion: This case emphasizes the need for a high index of clinical suspicion for CVID in patients presenting with recurrent sinopulmonary infections. Although intravenous immunoglobulin provides improvement in these patients, early diagnosis is the key to preventing significant morbidity and mortality and improving prognosis.

No MeSH data available.


Related in: MedlinePlus

CT scan of the chest. Bronchial wall thickening and dilatation predominantly in the lower lung zones consistent with bronchiectasis can be seen.
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Figure 1: CT scan of the chest. Bronchial wall thickening and dilatation predominantly in the lower lung zones consistent with bronchiectasis can be seen.

Mentions: A high-resolution CT thorax scan without contrast was carried out for better delineation of lung parenchyma and was significant for bronchial wall thickening and dilatation predominantly in the lower lung fields consistent with bronchiectasis (Figure 1).


A middle-aged female with recurrent sinopulmonary infections: a case report.

Yalavarthy UC, Panda M - J Med Case Rep (2008)

CT scan of the chest. Bronchial wall thickening and dilatation predominantly in the lower lung zones consistent with bronchiectasis can be seen.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2365966&req=5

Figure 1: CT scan of the chest. Bronchial wall thickening and dilatation predominantly in the lower lung zones consistent with bronchiectasis can be seen.
Mentions: A high-resolution CT thorax scan without contrast was carried out for better delineation of lung parenchyma and was significant for bronchial wall thickening and dilatation predominantly in the lower lung fields consistent with bronchiectasis (Figure 1).

Bottom Line: Physical examination was significant for bibasilar rhonchi.Laboratory data were significant for leukocytosis of 15,700/mm3.Although intravenous immunoglobulin provides improvement in these patients, early diagnosis is the key to preventing significant morbidity and mortality and improving prognosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine, University of Tennessee, College of Medicine-Chattanooga, Chattanooga, USA. umesheras@yahoo.ca

ABSTRACT

Introduction: Common variable immunodeficiency (CVID) is a form of severe antibody deficiency with an estimated prevalence of 1 in 25,000 to 1 in 100,000. The disorder apparently results from currently undefined immune deregulations resulting in failed B-cell differentiation with impaired secretion of immunoglobulins. It has a broad range of clinical symptoms including recurrent infections of the respiratory tract, chronic lung disease, autoimmune diseases, liver and gastrointestinal disorders, granulomatous infiltrations, lymphoma and solid tumors.

Case presentation: A 42-year-old Caucasian female presented with a one-day history of high-grade fever and productive cough associated with retrosternal chest pain. The patient had been discharged one week prior after a prolonged stay in an intensive care unit with multiorgan failure requiring temporary hemodialysis for two weeks secondary to sepsis. Past medical history was significant for chronic obstructive pulmonary disease, recurrent pneumonias and recurrent sinus infections since adolescence. She had a temperature of 99.8 degrees F, was tachycardic (137/min), tachypneic (26/min) with a blood pressure of 109/59 mmHg and oxygen saturation of 88% on 2 l/min nasal oxygen. Physical examination was significant for bibasilar rhonchi. Laboratory data were significant for leukocytosis of 15,700/mm3. Chest X-ray demonstrated bibasilar infiltrates. The patient was started on intravenous levofloxacin and vancomycin, and sputum gram stain and cultures were performed. Given the patient's recurrent respiratory infections, an underlying immunologic disorder was considered. Work-up revealed immunoglobulin A (IgA) 11 mg/dl (normal 70-400 mg/dl), immunoglobulin M (IgM) 2 mg/dl (normal 40-230 mg/dl) and IgG 53 mg/dl (normal 700-1,600 mg/dl). The patient was diagnosed with CVID and started on intravenous immunoglobulin. She was initially started on a four-week regimen of intravenous immunoglobulin, which was later switched to a three-week regimen as the patient had respiratory infections on the four-week regimen. She remained asymptomatic on a three times/week intravenous immunoglobulin regimen.

Conclusion: This case emphasizes the need for a high index of clinical suspicion for CVID in patients presenting with recurrent sinopulmonary infections. Although intravenous immunoglobulin provides improvement in these patients, early diagnosis is the key to preventing significant morbidity and mortality and improving prognosis.

No MeSH data available.


Related in: MedlinePlus