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Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer.

Sakakibara T, Hibi K, Koike M, Fujiwara M, Kodera Y, Ito K, Nakao A - Br. J. Cancer (2005)

Bottom Line: A significant increase in PAI-1 expression scores was observed in lymph node metastasis-positive CRCs (2.19 +/- 0.43) compared to negative ones (0.35 +/- 0.42) (P = 0.0037) as well as in distant metastasis-positive CRCs (3.50 +/- 1.18) compared to negative ones (0.99 +/- 0.30).Moreover, multivariate analysis revealed the PAI-1 expression score to be a strong and independent prognostic factor for CRC (P = 0.0432).These results suggested that PAI-1 might serve as a new parameter for the prediction of prognoses in CRC.

View Article: PubMed Central - PubMed

Affiliation: Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Japan.

ABSTRACT
To test the hypothesis that plasminogen activator inhibitor-1 (PAI-1) may serve as a candidate marker for the malignancy of colorectal cancer (CRC), we performed a quantitative RT-PCR for PAI-1 gene and evaluated the possible relationship between PAI-1 gene expression levels and clinicopathological findings in CRC. A significant increase in PAI-1 expression scores was observed in lymph node metastasis-positive CRCs (2.19 +/- 0.43) compared to negative ones (0.35 +/- 0.42) (P = 0.0037) as well as in distant metastasis-positive CRCs (3.50 +/- 1.18) compared to negative ones (0.99 +/- 0.30). The PAI-1 expression score markedly increased with the tumour stage (P = 0.0063; ANOVA test). Moreover, multivariate analysis revealed the PAI-1 expression score to be a strong and independent prognostic factor for CRC (P = 0.0432). These results suggested that PAI-1 might serve as a new parameter for the prediction of prognoses in CRC.

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Cumulative survival of patient groups according to PAI-1 expression scores (more or less than 2). High PAI-1 expression-score group showed significantly poorer survival rates than the low PAI-1 expression-score group (P<0.0001).
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fig5: Cumulative survival of patient groups according to PAI-1 expression scores (more or less than 2). High PAI-1 expression-score group showed significantly poorer survival rates than the low PAI-1 expression-score group (P<0.0001).

Mentions: To determine the role of PAI-1 expression in CRC, we examined the correlation of CRC expression scores with the clinicopathological features. Figure 1 shows the distribution of the PAI-1 expression scores (the average was 1.35±0.33). Figure 2 shows the differences in PAI-1 expression scores according to lymph node metastasis. A significant increase in PAI-1 expression scores was observed in lymph node metastasis-positive CRCs (2.19±0.43) compared to negative ones (0.35±0.42) (P=0.0037). Figure 3 shows the differences in PAI-1 expression scores according to distant metastasis. A significant increase in PAI-1 expression scores was observed in distant metastasis-positive CRCs (3.50±1.18) compared to negative ones (0.99±0.30). These results are summarised in Table 1. As shown in Figure 4, the PAI-1 expression score was significantly increased with the tumour stage (stage I=0.01±0.63, stage II=0.66±0.61, stage III=1.67±0.36, stage IV=3.50±1.18) (P=0.0063; ANOVA test). We then examined the cumulative survival of patient groups according to their PAI-1 expression scores (more or less than 2). Interestingly, the high PAI-1 expression-score group showed significantly poorer survival rates than the low PAI-1 expression-score group (Figure 5, P<0.0001).


Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer.

Sakakibara T, Hibi K, Koike M, Fujiwara M, Kodera Y, Ito K, Nakao A - Br. J. Cancer (2005)

Cumulative survival of patient groups according to PAI-1 expression scores (more or less than 2). High PAI-1 expression-score group showed significantly poorer survival rates than the low PAI-1 expression-score group (P<0.0001).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2361636&req=5

fig5: Cumulative survival of patient groups according to PAI-1 expression scores (more or less than 2). High PAI-1 expression-score group showed significantly poorer survival rates than the low PAI-1 expression-score group (P<0.0001).
Mentions: To determine the role of PAI-1 expression in CRC, we examined the correlation of CRC expression scores with the clinicopathological features. Figure 1 shows the distribution of the PAI-1 expression scores (the average was 1.35±0.33). Figure 2 shows the differences in PAI-1 expression scores according to lymph node metastasis. A significant increase in PAI-1 expression scores was observed in lymph node metastasis-positive CRCs (2.19±0.43) compared to negative ones (0.35±0.42) (P=0.0037). Figure 3 shows the differences in PAI-1 expression scores according to distant metastasis. A significant increase in PAI-1 expression scores was observed in distant metastasis-positive CRCs (3.50±1.18) compared to negative ones (0.99±0.30). These results are summarised in Table 1. As shown in Figure 4, the PAI-1 expression score was significantly increased with the tumour stage (stage I=0.01±0.63, stage II=0.66±0.61, stage III=1.67±0.36, stage IV=3.50±1.18) (P=0.0063; ANOVA test). We then examined the cumulative survival of patient groups according to their PAI-1 expression scores (more or less than 2). Interestingly, the high PAI-1 expression-score group showed significantly poorer survival rates than the low PAI-1 expression-score group (Figure 5, P<0.0001).

Bottom Line: A significant increase in PAI-1 expression scores was observed in lymph node metastasis-positive CRCs (2.19 +/- 0.43) compared to negative ones (0.35 +/- 0.42) (P = 0.0037) as well as in distant metastasis-positive CRCs (3.50 +/- 1.18) compared to negative ones (0.99 +/- 0.30).Moreover, multivariate analysis revealed the PAI-1 expression score to be a strong and independent prognostic factor for CRC (P = 0.0432).These results suggested that PAI-1 might serve as a new parameter for the prediction of prognoses in CRC.

View Article: PubMed Central - PubMed

Affiliation: Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Japan.

ABSTRACT
To test the hypothesis that plasminogen activator inhibitor-1 (PAI-1) may serve as a candidate marker for the malignancy of colorectal cancer (CRC), we performed a quantitative RT-PCR for PAI-1 gene and evaluated the possible relationship between PAI-1 gene expression levels and clinicopathological findings in CRC. A significant increase in PAI-1 expression scores was observed in lymph node metastasis-positive CRCs (2.19 +/- 0.43) compared to negative ones (0.35 +/- 0.42) (P = 0.0037) as well as in distant metastasis-positive CRCs (3.50 +/- 1.18) compared to negative ones (0.99 +/- 0.30). The PAI-1 expression score markedly increased with the tumour stage (P = 0.0063; ANOVA test). Moreover, multivariate analysis revealed the PAI-1 expression score to be a strong and independent prognostic factor for CRC (P = 0.0432). These results suggested that PAI-1 might serve as a new parameter for the prediction of prognoses in CRC.

Show MeSH
Related in: MedlinePlus