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Intensive induction chemotherapy with C-BOP/BEP for intermediate- and poor-risk metastatic germ cell tumours (EORTC trial 30948).

Fosså SD, Paluchowska B, Horwich A, Kaiser G, de Mulder PH, Koriakine O, van Oosterom AT, de Prijck L, Collette L, de Wit R, EORTC GU Gro - Br. J. Cancer (2005)

Bottom Line: The 2-year overall survival was 84.5% (95% CI: 75.6-93.3%).In all, 51 patients experienced at least one episode of WHO grade 3/4 leucopenia, and at least one event of grade 3/4 thrombocytopenia occurred in 30 patients.There was no toxic death.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway. s.d.fossa@klinmed.uio.no

ABSTRACT
New chemotherapy regimens are continuously explored in patients with high-risk malignant germ cell tumours (MGCTs). This multicentre phase II trial assessed the efficacy and toxicity of C-BOP/BEP chemotherapy in intermediate and poor prognosis MGCT (IGCCCG criteria). C-BOP/BEP treatment consisted of cycles of cisplatin, vincristine, bleomycin and carboplatin, followed by one cycle of vincristine and bleomycin and three cycles of BEP (bleomycon, etoposide, cisplatin). The trial was designed to demonstrate a 1-year progression-free survival rate of 80%, that is, to exclude a 1-year rate of 70% or less, with a one-sided significance level of 5%. Secondary end points included toxicity, overall survival and the postchemotherapy complete response rate. In total, 16 European hospitals entered 66 eligible patients (intermediate prognosis group: 37; poor prognosis group: 29). A total of 45 patients (68.2%, 95% confidence interval (95% CI): 56.9-79.4%) achieved a complete response (intermediate prognosis: 30; poor prognosis: 15). After a median observation time of 40.4 months (range: 13.7-66.3), the 1-year progression-free survival rate was 81.8% 95% CI: 72.5-91.1%). The 2-year overall survival was 84.5% (95% CI: 75.6-93.3%). In all, 51 patients experienced at least one episode of WHO grade 3/4 leucopenia, and at least one event of grade 3/4 thrombocytopenia occurred in 30 patients. There was no toxic death. With an 82% 1-year progression-free survival and a lower limit of the 95% CI above 70%, the efficacy of C-BOP/BEP is comparable to that of published alternative chemotherapy schedules in high-risk MGCT patients. The treatment's toxicity is manageable in a multicentre setting. In poor prognosis patients, C-BOP/BEP should be compared to standard chemotherapy of four cycles of BEP.

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Related in: MedlinePlus

Progression-free (A) and overall (B) survival in patients with MGCT of the intermediate (37 patients) and poor prognosis (29 patients) group.
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fig1: Progression-free (A) and overall (B) survival in patients with MGCT of the intermediate (37 patients) and poor prognosis (29 patients) group.

Mentions: The 1-year progression-free survival for all patients was 81.8% (95% CI: 72.5–91.1%). The 2-year progression-free survival for the intermediate- and high-risk group was 89.7% (95% CI: 80.2–99.3%) and 55.6% (95% CI: 36.8–74.3%), respectively (Figure 1A). The 1- and 2-year overall survivals were, respectively, 93.9% (95% CI: 88.2–99.7%) and 84.5% (95% CI: 75.6–93.3%) (Figure 1B).


Intensive induction chemotherapy with C-BOP/BEP for intermediate- and poor-risk metastatic germ cell tumours (EORTC trial 30948).

Fosså SD, Paluchowska B, Horwich A, Kaiser G, de Mulder PH, Koriakine O, van Oosterom AT, de Prijck L, Collette L, de Wit R, EORTC GU Gro - Br. J. Cancer (2005)

Progression-free (A) and overall (B) survival in patients with MGCT of the intermediate (37 patients) and poor prognosis (29 patients) group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2361516&req=5

fig1: Progression-free (A) and overall (B) survival in patients with MGCT of the intermediate (37 patients) and poor prognosis (29 patients) group.
Mentions: The 1-year progression-free survival for all patients was 81.8% (95% CI: 72.5–91.1%). The 2-year progression-free survival for the intermediate- and high-risk group was 89.7% (95% CI: 80.2–99.3%) and 55.6% (95% CI: 36.8–74.3%), respectively (Figure 1A). The 1- and 2-year overall survivals were, respectively, 93.9% (95% CI: 88.2–99.7%) and 84.5% (95% CI: 75.6–93.3%) (Figure 1B).

Bottom Line: The 2-year overall survival was 84.5% (95% CI: 75.6-93.3%).In all, 51 patients experienced at least one episode of WHO grade 3/4 leucopenia, and at least one event of grade 3/4 thrombocytopenia occurred in 30 patients.There was no toxic death.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway. s.d.fossa@klinmed.uio.no

ABSTRACT
New chemotherapy regimens are continuously explored in patients with high-risk malignant germ cell tumours (MGCTs). This multicentre phase II trial assessed the efficacy and toxicity of C-BOP/BEP chemotherapy in intermediate and poor prognosis MGCT (IGCCCG criteria). C-BOP/BEP treatment consisted of cycles of cisplatin, vincristine, bleomycin and carboplatin, followed by one cycle of vincristine and bleomycin and three cycles of BEP (bleomycon, etoposide, cisplatin). The trial was designed to demonstrate a 1-year progression-free survival rate of 80%, that is, to exclude a 1-year rate of 70% or less, with a one-sided significance level of 5%. Secondary end points included toxicity, overall survival and the postchemotherapy complete response rate. In total, 16 European hospitals entered 66 eligible patients (intermediate prognosis group: 37; poor prognosis group: 29). A total of 45 patients (68.2%, 95% confidence interval (95% CI): 56.9-79.4%) achieved a complete response (intermediate prognosis: 30; poor prognosis: 15). After a median observation time of 40.4 months (range: 13.7-66.3), the 1-year progression-free survival rate was 81.8% 95% CI: 72.5-91.1%). The 2-year overall survival was 84.5% (95% CI: 75.6-93.3%). In all, 51 patients experienced at least one episode of WHO grade 3/4 leucopenia, and at least one event of grade 3/4 thrombocytopenia occurred in 30 patients. There was no toxic death. With an 82% 1-year progression-free survival and a lower limit of the 95% CI above 70%, the efficacy of C-BOP/BEP is comparable to that of published alternative chemotherapy schedules in high-risk MGCT patients. The treatment's toxicity is manageable in a multicentre setting. In poor prognosis patients, C-BOP/BEP should be compared to standard chemotherapy of four cycles of BEP.

Show MeSH
Related in: MedlinePlus