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Thrombomodulin expression in colorectal carcinoma is protective and correlates with survival.

Hanly AM, Redmond M, Winter DC, Brophy S, Deasy JM, Bouchier-Hayes DJ, Kay EW - Br. J. Cancer (2006)

Bottom Line: TM expression decreases as overall stage and tumour size increase (P=0.03).Survival rate was poorer in those patients who were TM negative compared with those who were positive (P<0.01).This study demonstrates that loss of TM is a key indicator in tumour biology and prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

ABSTRACT
Thrombomodulin (TM) is an endothelial receptor that exhibits anticoagulant, antifibrinolytic and anti-inflammatory activity by inhibiting thrombin and cellular adhesion. In this study, the expression and significance of TM was examined in primary colorectal cancer and its prognostic implications explored. TM immunostaining was performed on formalin-fixed, paraffin-embedded tissue sections, from primary lesions of 200 patients with colorectal carcinoma. Institutional Ethical approval was granted and clinical data retrieved from patients' records. All normal colonic tissue expressed TM on endothelial cells. TM tumour cell expression was demonstrated in 53 (26.5%) cases and 147 (73.5%) showed no neoplastic cell staining. On univariate and multivariate analysis TM expression on tumour cells correlated significantly with tumour stage, differentiation, Jass score and 5 year survival. TM expression decreases as overall stage and tumour size increase (P=0.03). In all, 91% TM positive tumours were well differentiated and 85% of TM negative tumours were poorly differentiated (P<0.01). Five year survival rates of patients with positive and negative TM expression were 71 and 41%, respectively. Survival rate was poorer in those patients who were TM negative compared with those who were positive (P<0.01). A total of 101 (50.5%) of the cases were node negative. In this group, 5 year survival rates of patients with positive and negative TM expression were 87.5 and 37.8%, respectively, demonstrating a poorer survival rate for those who are node negative and TM negative at the time of surgery (P<0.001). This study demonstrates that loss of TM is a key indicator in tumour biology and prognosis.

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Related in: MedlinePlus

Comparison of the survival between groups which are TM positive and TM negative. The patients who were TM negative showed a significantly poorer survival than those who were TM positive.
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fig6: Comparison of the survival between groups which are TM positive and TM negative. The patients who were TM negative showed a significantly poorer survival than those who were TM positive.

Mentions: A survival analysis was carried out using the Kaplan–Meier method. Clinical data was complete in 100% of patients. Of the 200 patients included in this study 35 (17.5%) experienced noncancer-related deaths and were considered censored in the Kaplan–Meier survival analysis. Comparisons were then made with survival and TM expression groups in the primary tumour. The 5 year survival rates of patients with positive and negative TM expression were 71 and 41%, respectively (P<0.01) (Figure 6).


Thrombomodulin expression in colorectal carcinoma is protective and correlates with survival.

Hanly AM, Redmond M, Winter DC, Brophy S, Deasy JM, Bouchier-Hayes DJ, Kay EW - Br. J. Cancer (2006)

Comparison of the survival between groups which are TM positive and TM negative. The patients who were TM negative showed a significantly poorer survival than those who were TM positive.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2361416&req=5

fig6: Comparison of the survival between groups which are TM positive and TM negative. The patients who were TM negative showed a significantly poorer survival than those who were TM positive.
Mentions: A survival analysis was carried out using the Kaplan–Meier method. Clinical data was complete in 100% of patients. Of the 200 patients included in this study 35 (17.5%) experienced noncancer-related deaths and were considered censored in the Kaplan–Meier survival analysis. Comparisons were then made with survival and TM expression groups in the primary tumour. The 5 year survival rates of patients with positive and negative TM expression were 71 and 41%, respectively (P<0.01) (Figure 6).

Bottom Line: TM expression decreases as overall stage and tumour size increase (P=0.03).Survival rate was poorer in those patients who were TM negative compared with those who were positive (P<0.01).This study demonstrates that loss of TM is a key indicator in tumour biology and prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

ABSTRACT
Thrombomodulin (TM) is an endothelial receptor that exhibits anticoagulant, antifibrinolytic and anti-inflammatory activity by inhibiting thrombin and cellular adhesion. In this study, the expression and significance of TM was examined in primary colorectal cancer and its prognostic implications explored. TM immunostaining was performed on formalin-fixed, paraffin-embedded tissue sections, from primary lesions of 200 patients with colorectal carcinoma. Institutional Ethical approval was granted and clinical data retrieved from patients' records. All normal colonic tissue expressed TM on endothelial cells. TM tumour cell expression was demonstrated in 53 (26.5%) cases and 147 (73.5%) showed no neoplastic cell staining. On univariate and multivariate analysis TM expression on tumour cells correlated significantly with tumour stage, differentiation, Jass score and 5 year survival. TM expression decreases as overall stage and tumour size increase (P=0.03). In all, 91% TM positive tumours were well differentiated and 85% of TM negative tumours were poorly differentiated (P<0.01). Five year survival rates of patients with positive and negative TM expression were 71 and 41%, respectively. Survival rate was poorer in those patients who were TM negative compared with those who were positive (P<0.01). A total of 101 (50.5%) of the cases were node negative. In this group, 5 year survival rates of patients with positive and negative TM expression were 87.5 and 37.8%, respectively, demonstrating a poorer survival rate for those who are node negative and TM negative at the time of surgery (P<0.001). This study demonstrates that loss of TM is a key indicator in tumour biology and prognosis.

Show MeSH
Related in: MedlinePlus