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Rationale for multiple risk intervention: the need to move from theory to practice.

Erhardt LR - Vasc Health Risk Manag (2007)

Bottom Line: These factors, such as low-density lipoprotein (LDL)-cholesterol, elevated blood pressure, obesity, and insulin resistance have a continuous, progressive impact on total CV risk, with higher levels and numbers of factors translating into greater risk.Effective and well-tolerated pharmacotherapies are available for the treatment of risk-factors.Patient compliance and persistence to available therapies is also necessary for successful modulation of CVD risk.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Sciences, Medicine, Lund University, Malmö University Hospital, Malmö, Sweden. leif.erhardt@med.lu.se

ABSTRACT
Incidence of cardiovascular (CV) and metabolic disease is increasing, in parallel with associated risk factors. These factors, such as low-density lipoprotein (LDL)-cholesterol, elevated blood pressure, obesity, and insulin resistance have a continuous, progressive impact on total CV risk, with higher levels and numbers of factors translating into greater risk. Evaluation of all known modifiable risk factors, to provide a detailed total CV disease (CVD) and metabolic risk-status profile is therefore necessary to ensure appropriate treatment of each factor within the context of a multifactorial, global approach to prevention of CVD and metabolic disease. Effective and well-tolerated pharmacotherapies are available for the treatment of risk-factors. Realization of the potential health and economic benefits of effective risk factor management requires improved risk factor screening, early and aggressive treatment, improved public health support (ie, education and guidelines), and appropriate therapeutic interventions based on current guidelines and accurate risk assessment. Patient compliance and persistence to available therapies is also necessary for successful modulation of CVD risk.

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Related in: MedlinePlus

Change in risk for cardiovascular disease deaths with increasing age (based on the European Society of Cardiology (ESC) SCORE chart) for a woman in a high-risk population who smokes and has high cholesterol and high blood pressure, compared with a nonsmoker with lower cholesterol and blood pressure values. Data drawn from Conroy RM, Pyorala K, Fitzgerald AP, et al 2003. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J, 24:987–1003.
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fig3: Change in risk for cardiovascular disease deaths with increasing age (based on the European Society of Cardiology (ESC) SCORE chart) for a woman in a high-risk population who smokes and has high cholesterol and high blood pressure, compared with a nonsmoker with lower cholesterol and blood pressure values. Data drawn from Conroy RM, Pyorala K, Fitzgerald AP, et al 2003. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J, 24:987–1003.

Mentions: Figure 3 is based on the European Society of Cardiology (ESC) SCORE chart (Conroy et al 2003) and shows how age alone changes the 10-year risk if a patient with the same risk profile is seen at different age brackets. It is also clear that young individuals are at lower risk even in the presence of significant risk factors, and there is the potential for lowering risk if treatment is initiated earlier.


Rationale for multiple risk intervention: the need to move from theory to practice.

Erhardt LR - Vasc Health Risk Manag (2007)

Change in risk for cardiovascular disease deaths with increasing age (based on the European Society of Cardiology (ESC) SCORE chart) for a woman in a high-risk population who smokes and has high cholesterol and high blood pressure, compared with a nonsmoker with lower cholesterol and blood pressure values. Data drawn from Conroy RM, Pyorala K, Fitzgerald AP, et al 2003. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J, 24:987–1003.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2350141&req=5

fig3: Change in risk for cardiovascular disease deaths with increasing age (based on the European Society of Cardiology (ESC) SCORE chart) for a woman in a high-risk population who smokes and has high cholesterol and high blood pressure, compared with a nonsmoker with lower cholesterol and blood pressure values. Data drawn from Conroy RM, Pyorala K, Fitzgerald AP, et al 2003. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J, 24:987–1003.
Mentions: Figure 3 is based on the European Society of Cardiology (ESC) SCORE chart (Conroy et al 2003) and shows how age alone changes the 10-year risk if a patient with the same risk profile is seen at different age brackets. It is also clear that young individuals are at lower risk even in the presence of significant risk factors, and there is the potential for lowering risk if treatment is initiated earlier.

Bottom Line: These factors, such as low-density lipoprotein (LDL)-cholesterol, elevated blood pressure, obesity, and insulin resistance have a continuous, progressive impact on total CV risk, with higher levels and numbers of factors translating into greater risk.Effective and well-tolerated pharmacotherapies are available for the treatment of risk-factors.Patient compliance and persistence to available therapies is also necessary for successful modulation of CVD risk.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Sciences, Medicine, Lund University, Malmö University Hospital, Malmö, Sweden. leif.erhardt@med.lu.se

ABSTRACT
Incidence of cardiovascular (CV) and metabolic disease is increasing, in parallel with associated risk factors. These factors, such as low-density lipoprotein (LDL)-cholesterol, elevated blood pressure, obesity, and insulin resistance have a continuous, progressive impact on total CV risk, with higher levels and numbers of factors translating into greater risk. Evaluation of all known modifiable risk factors, to provide a detailed total CV disease (CVD) and metabolic risk-status profile is therefore necessary to ensure appropriate treatment of each factor within the context of a multifactorial, global approach to prevention of CVD and metabolic disease. Effective and well-tolerated pharmacotherapies are available for the treatment of risk-factors. Realization of the potential health and economic benefits of effective risk factor management requires improved risk factor screening, early and aggressive treatment, improved public health support (ie, education and guidelines), and appropriate therapeutic interventions based on current guidelines and accurate risk assessment. Patient compliance and persistence to available therapies is also necessary for successful modulation of CVD risk.

Show MeSH
Related in: MedlinePlus