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The underlying mechanisms for development of hypertension in the metabolic syndrome.

Yanai H, Tomono Y, Ito K, Furutani N, Yoshida H, Tada N - Nutr J (2008)

Bottom Line: High blood pressure is an important constituent of the metabolic syndrome.Visceral/central obesity, insulin resistance, sympathetic overactivity, oxidative stress, endothelial dysfunction, activated renin-angiotensin system, increased inflammatory mediators, and obstructive sleep apnea have been suggested to be possible factors to develop hypertension in the metabolic syndrome.Here, we will discuss how these factors influence on development of hypertension in the metabolic syndrome.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan. yanaih@jikei.ac.jp

ABSTRACT
High blood pressure is an important constituent of the metabolic syndrome. However, the underlying mechanisms for development of hypertension in the metabolic syndrome are very complicated and remain still obscure. Visceral/central obesity, insulin resistance, sympathetic overactivity, oxidative stress, endothelial dysfunction, activated renin-angiotensin system, increased inflammatory mediators, and obstructive sleep apnea have been suggested to be possible factors to develop hypertension in the metabolic syndrome. Here, we will discuss how these factors influence on development of hypertension in the metabolic syndrome.

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Proposed mechanisms for development of hypertension in the metabolic syndrome. IL-6, interleukin-6; NEFA, non-esterified fatty acids; TNF-α, tumor necrosis factor-α; OSA, obstructive sleep apnea.
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Figure 1: Proposed mechanisms for development of hypertension in the metabolic syndrome. IL-6, interleukin-6; NEFA, non-esterified fatty acids; TNF-α, tumor necrosis factor-α; OSA, obstructive sleep apnea.

Mentions: Proposed mechanisms for development of hypertension in the metabolic syndrome were shown in Figure 1.


The underlying mechanisms for development of hypertension in the metabolic syndrome.

Yanai H, Tomono Y, Ito K, Furutani N, Yoshida H, Tada N - Nutr J (2008)

Proposed mechanisms for development of hypertension in the metabolic syndrome. IL-6, interleukin-6; NEFA, non-esterified fatty acids; TNF-α, tumor necrosis factor-α; OSA, obstructive sleep apnea.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2335113&req=5

Figure 1: Proposed mechanisms for development of hypertension in the metabolic syndrome. IL-6, interleukin-6; NEFA, non-esterified fatty acids; TNF-α, tumor necrosis factor-α; OSA, obstructive sleep apnea.
Mentions: Proposed mechanisms for development of hypertension in the metabolic syndrome were shown in Figure 1.

Bottom Line: High blood pressure is an important constituent of the metabolic syndrome.Visceral/central obesity, insulin resistance, sympathetic overactivity, oxidative stress, endothelial dysfunction, activated renin-angiotensin system, increased inflammatory mediators, and obstructive sleep apnea have been suggested to be possible factors to develop hypertension in the metabolic syndrome.Here, we will discuss how these factors influence on development of hypertension in the metabolic syndrome.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan. yanaih@jikei.ac.jp

ABSTRACT
High blood pressure is an important constituent of the metabolic syndrome. However, the underlying mechanisms for development of hypertension in the metabolic syndrome are very complicated and remain still obscure. Visceral/central obesity, insulin resistance, sympathetic overactivity, oxidative stress, endothelial dysfunction, activated renin-angiotensin system, increased inflammatory mediators, and obstructive sleep apnea have been suggested to be possible factors to develop hypertension in the metabolic syndrome. Here, we will discuss how these factors influence on development of hypertension in the metabolic syndrome.

Show MeSH
Related in: MedlinePlus