Meeting Abstracts. Recent Developments in 1,3-beta-Glucan Biology: Proceedings of the 5th Glucan Symposium Tokyo, December 8, 2006.
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Mentions: It is widely recognized that cell wall components of microorganisms may induce variety of host reactions. The cell wall component lipopolysaccharide of Gram-negative bacteria and peptidoglycan of Gram-positive bacteria can activate macrophages to release proinflammatory molecules, resulting in circulatory shock and multiple organ failure [1, 2]. On the other hand, the bioactivity of cell wall component(s) of fungi has not been fully elucidated, especially in vivo. In a previous study, we isolated soluble 1,3-β-glucan (CSBG) from Candida albicans . In the current work, we investigated the effects of CSBG on the respiratory systems in mice after an intratracheal injection of 50 μg. The animals were sacrificed at 24 hours after this exposure, then, a broncho-alveolar lavage was performed, and the cells were stained with Diff-Quick. The results on cells are found in Figure 1.