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The peroxisome: a production in four acts.

Rout MP - J. Cell Biol. (2008)

Bottom Line: Long-O'Donnell, R.A.Rachubinski, and J.D.Aitchison. 2008.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA. rout@rockefeller.edu

ABSTRACT
A cell regulates the number, size, and kind of each organelle it possesses in response to its particular role in an environment or tissue. Yet we still know little about how the molecular signaling networks within each cell perform such regulation. In this issue, Saleem et al. (Saleem, R.A., B. Knoblach, F.D. Mast, J.J. Smith, J. Boyle, C.M. Dobson, R. Long-O'Donnell, R.A. Rachubinski, and J.D. Aitchison. 2008. J. Cell Biol. 181:281-292) show for the first time how groups of kinases and phosphatases are organized to control when and how a cell assembles one kind of organelle, the peroxisome.

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Induction of yeast peroxisomes over a 20-h period in oleic acid, visualized by the Pot1p-GFP reporter, showing how yeast can fill themselves with many peroxisomes in a remarkably short time. This image appears courtesy of R. Saleem and J. Aitchison. Bar, 5 μm.
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fig1: Induction of yeast peroxisomes over a 20-h period in oleic acid, visualized by the Pot1p-GFP reporter, showing how yeast can fill themselves with many peroxisomes in a remarkably short time. This image appears courtesy of R. Saleem and J. Aitchison. Bar, 5 μm.

Mentions: In the model organism Saccharomyces cerevisiae (baker's yeast), peroxisomes are low in number during growth in which sugars are the source of carbon. However, yeast respond by rapidly inducing peroxisome biogenesis when switched to a medium in which fatty acids supply the carbon (Fig. 1), enabling researchers to identify many genes required for peroxisome assembly. Importantly, mutants in these genes often mimic human peroxisome biogenesis disorders including Zellweger syndrome (Subramani, 1997).


The peroxisome: a production in four acts.

Rout MP - J. Cell Biol. (2008)

Induction of yeast peroxisomes over a 20-h period in oleic acid, visualized by the Pot1p-GFP reporter, showing how yeast can fill themselves with many peroxisomes in a remarkably short time. This image appears courtesy of R. Saleem and J. Aitchison. Bar, 5 μm.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2315666&req=5

fig1: Induction of yeast peroxisomes over a 20-h period in oleic acid, visualized by the Pot1p-GFP reporter, showing how yeast can fill themselves with many peroxisomes in a remarkably short time. This image appears courtesy of R. Saleem and J. Aitchison. Bar, 5 μm.
Mentions: In the model organism Saccharomyces cerevisiae (baker's yeast), peroxisomes are low in number during growth in which sugars are the source of carbon. However, yeast respond by rapidly inducing peroxisome biogenesis when switched to a medium in which fatty acids supply the carbon (Fig. 1), enabling researchers to identify many genes required for peroxisome assembly. Importantly, mutants in these genes often mimic human peroxisome biogenesis disorders including Zellweger syndrome (Subramani, 1997).

Bottom Line: Long-O'Donnell, R.A.Rachubinski, and J.D.Aitchison. 2008.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA. rout@rockefeller.edu

ABSTRACT
A cell regulates the number, size, and kind of each organelle it possesses in response to its particular role in an environment or tissue. Yet we still know little about how the molecular signaling networks within each cell perform such regulation. In this issue, Saleem et al. (Saleem, R.A., B. Knoblach, F.D. Mast, J.J. Smith, J. Boyle, C.M. Dobson, R. Long-O'Donnell, R.A. Rachubinski, and J.D. Aitchison. 2008. J. Cell Biol. 181:281-292) show for the first time how groups of kinases and phosphatases are organized to control when and how a cell assembles one kind of organelle, the peroxisome.

Show MeSH
Related in: MedlinePlus