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Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals.

Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, Rasmussen C, Greenwood M, Leutholtz B, Willoughby D, Kreider R - J Int Soc Sports Nutr (2008)

Bottom Line: Subjects were then given 200 mg of the placebo or the CoQ10 supplement.Data was analyzed using repeated measures ANOVA with an alpha of 0.05.A trend for lower serum superoxide dismutase (SOD) was observed following acute supplementation with CoQ10 (p = 0.06), whereas serum malondialdehyde (MDA) tended to be significantly higher (p < 0.05).

View Article: PubMed Central - HTML - PubMed

Affiliation: Exercise & Sport Nutrition Lab; Center for Exercise, Nutrition and Preventive Health; Department of Health, Human Performance & Recreation; Baylor University; Waco, TX, USA. matt_cooke@baylor.edu

ABSTRACT

Background: To determine whether acute (single dose) and/or chronic (14-days) supplementation of CoQ10 will improve anaerobic and/or aerobic exercise performance by increasing plasma and muscle CoQ10 concentrations within trained and untrained individuals.

Methods: Twenty-two aerobically trained and nineteen untrained male and female subjects (26.1 +/- 7.6 yrs, 172 +/- 8.7 cm, 73.5 +/- 17 kg, and 21.2 +/- 7.0%) were randomized to ingest in a double-blind manner either 100 mg of a dextrose placebo (CON) or a fast-melt CoQ10 supplement (CoQ10) twice a day for 14-days. On the first day of supplementation, subjects donated fasting blood samples and a muscle biopsy. Subjects were then given 200 mg of the placebo or the CoQ10 supplement. Sixty minutes following supplement ingestion, subjects completed an isokinetic knee extension endurance test, a 30-second wingate anaerobic capacity test, and a maximal cardiopulmonary graded exercise test interspersed with 30-minutes of recovery. Additional blood samples were taken immediately following each exercise test and a second muscle biopsy sample was taken following the final exercise test. Subjects consumed twice daily (morning and night), 100 mg of either supplement for a period of 14-days, and then returned to the lab to complete the same battery of tests. Data was analyzed using repeated measures ANOVA with an alpha of 0.05.

Results: Plasma CoQ10 levels were significantly increased following 2 weeks of CoQ10 supplementation (p < 0.001); while a trend for higher muscle CoQ10 levels was observed after acute CoQ10 ingestion (p = 0.098). A trend for lower serum superoxide dismutase (SOD) was observed following acute supplementation with CoQ10 (p = 0.06), whereas serum malondialdehyde (MDA) tended to be significantly higher (p < 0.05). Following acute ingestion of CoQ10, plasma CoQ10 levels were significantly correlated to muscle CoQ10 levels; maximal oxygen consumption; and treadmill time to exhaustion. A trend for increased time to exhaustion was observed following 2 weeks of CoQ10 supplementation (p = 0.06).

Conclusion: Acute supplementation with CoQ10 resulted in higher muscle CoQ10 concentration, lower serum SOD oxidative stress, and higher MDA levels during and following exercise. Chronic CoQ10 supplementation increased plasma CoQ10 concentrations and tended to increase time to exhaustion. Results indicate that acute and chronic supplementation of CoQ10 may affect acute and/or chronic responses to various types of exercise.

No MeSH data available.


Related in: MedlinePlus

Delta changes from baseline for muscle CoQ10 concentration. Data (mean ± SD) represents delta scores (post minus pre values) for each performance test (Isokinetic, Wingate, Cardiopulmonary), both CoQ10 and placebo control groups on day 0 (T2) and day 14 (T3).
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Figure 4: Delta changes from baseline for muscle CoQ10 concentration. Data (mean ± SD) represents delta scores (post minus pre values) for each performance test (Isokinetic, Wingate, Cardiopulmonary), both CoQ10 and placebo control groups on day 0 (T2) and day 14 (T3).

Mentions: Similar to Zhou and coworkers [3], results from the present study showed a significant increase in plasma CoQ10 concentration following chronic supplementation. However, contrary to the observations of Zhou et al., [3], the present study showed a strong trend (p = 0.06) for increased time to exhaustion following CoQ10 supplementation. In addition, acute CoQ10 supplementation tended to increase CoQ10 levels within the muscle, albeit not significantly (p = 0.09). Though no significant changes were observed following chronic supplementation, it is evident from Figure 4 that muscle CoQ10 concentration was generally higher after baseline in the CoQ10-supplemented group compared to placebo group. In fact, muscle CoQ10 levels declined in the placebo group over the 2-week period. These findings indicate that ingestion of a fast-melt form of CoQ10 will increase plasma availability of CoQ10 and may also influence muscle concentrations on an acute and/or chronic basis. However, more research is needed before definitive conclusions can be drawn.


Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals.

Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, Rasmussen C, Greenwood M, Leutholtz B, Willoughby D, Kreider R - J Int Soc Sports Nutr (2008)

Delta changes from baseline for muscle CoQ10 concentration. Data (mean ± SD) represents delta scores (post minus pre values) for each performance test (Isokinetic, Wingate, Cardiopulmonary), both CoQ10 and placebo control groups on day 0 (T2) and day 14 (T3).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2315638&req=5

Figure 4: Delta changes from baseline for muscle CoQ10 concentration. Data (mean ± SD) represents delta scores (post minus pre values) for each performance test (Isokinetic, Wingate, Cardiopulmonary), both CoQ10 and placebo control groups on day 0 (T2) and day 14 (T3).
Mentions: Similar to Zhou and coworkers [3], results from the present study showed a significant increase in plasma CoQ10 concentration following chronic supplementation. However, contrary to the observations of Zhou et al., [3], the present study showed a strong trend (p = 0.06) for increased time to exhaustion following CoQ10 supplementation. In addition, acute CoQ10 supplementation tended to increase CoQ10 levels within the muscle, albeit not significantly (p = 0.09). Though no significant changes were observed following chronic supplementation, it is evident from Figure 4 that muscle CoQ10 concentration was generally higher after baseline in the CoQ10-supplemented group compared to placebo group. In fact, muscle CoQ10 levels declined in the placebo group over the 2-week period. These findings indicate that ingestion of a fast-melt form of CoQ10 will increase plasma availability of CoQ10 and may also influence muscle concentrations on an acute and/or chronic basis. However, more research is needed before definitive conclusions can be drawn.

Bottom Line: Subjects were then given 200 mg of the placebo or the CoQ10 supplement.Data was analyzed using repeated measures ANOVA with an alpha of 0.05.A trend for lower serum superoxide dismutase (SOD) was observed following acute supplementation with CoQ10 (p = 0.06), whereas serum malondialdehyde (MDA) tended to be significantly higher (p < 0.05).

View Article: PubMed Central - HTML - PubMed

Affiliation: Exercise & Sport Nutrition Lab; Center for Exercise, Nutrition and Preventive Health; Department of Health, Human Performance & Recreation; Baylor University; Waco, TX, USA. matt_cooke@baylor.edu

ABSTRACT

Background: To determine whether acute (single dose) and/or chronic (14-days) supplementation of CoQ10 will improve anaerobic and/or aerobic exercise performance by increasing plasma and muscle CoQ10 concentrations within trained and untrained individuals.

Methods: Twenty-two aerobically trained and nineteen untrained male and female subjects (26.1 +/- 7.6 yrs, 172 +/- 8.7 cm, 73.5 +/- 17 kg, and 21.2 +/- 7.0%) were randomized to ingest in a double-blind manner either 100 mg of a dextrose placebo (CON) or a fast-melt CoQ10 supplement (CoQ10) twice a day for 14-days. On the first day of supplementation, subjects donated fasting blood samples and a muscle biopsy. Subjects were then given 200 mg of the placebo or the CoQ10 supplement. Sixty minutes following supplement ingestion, subjects completed an isokinetic knee extension endurance test, a 30-second wingate anaerobic capacity test, and a maximal cardiopulmonary graded exercise test interspersed with 30-minutes of recovery. Additional blood samples were taken immediately following each exercise test and a second muscle biopsy sample was taken following the final exercise test. Subjects consumed twice daily (morning and night), 100 mg of either supplement for a period of 14-days, and then returned to the lab to complete the same battery of tests. Data was analyzed using repeated measures ANOVA with an alpha of 0.05.

Results: Plasma CoQ10 levels were significantly increased following 2 weeks of CoQ10 supplementation (p < 0.001); while a trend for higher muscle CoQ10 levels was observed after acute CoQ10 ingestion (p = 0.098). A trend for lower serum superoxide dismutase (SOD) was observed following acute supplementation with CoQ10 (p = 0.06), whereas serum malondialdehyde (MDA) tended to be significantly higher (p < 0.05). Following acute ingestion of CoQ10, plasma CoQ10 levels were significantly correlated to muscle CoQ10 levels; maximal oxygen consumption; and treadmill time to exhaustion. A trend for increased time to exhaustion was observed following 2 weeks of CoQ10 supplementation (p = 0.06).

Conclusion: Acute supplementation with CoQ10 resulted in higher muscle CoQ10 concentration, lower serum SOD oxidative stress, and higher MDA levels during and following exercise. Chronic CoQ10 supplementation increased plasma CoQ10 concentrations and tended to increase time to exhaustion. Results indicate that acute and chronic supplementation of CoQ10 may affect acute and/or chronic responses to various types of exercise.

No MeSH data available.


Related in: MedlinePlus