Limits...
Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology.

Deocaris CC, Widodo N, Wadhwa R, Kaul SC - J Transl Med (2008)

Bottom Line: Ayurveda is one of the ancient systems of health care of Indian origin.Although sheltered with long history and high trust, ayurveda principles have not entered laboratories and only a handful of studies have identified pure components and molecular pathways for its life-enhancing effects.We illustrate here the merger of ayurveda and functional genomics in a systems biology scenario that reveals the pathway analysis of crude and active components and inspire ayurveda practice for health benefits, disease prevention and therapeutics.

View Article: PubMed Central - HTML - PubMed

Affiliation: National Institute of Advanced Industrial Science & Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. custerd@biochem.taiiku.tsukuba.ac.jp

ABSTRACT
Ayurveda is one of the ancient systems of health care of Indian origin. Roughly translated into "Knowledge of life", it is based on the use of natural herbs and herb products for therapeutic measures to boost physical, mental, social and spiritual harmony and improve quality of life. Although sheltered with long history and high trust, ayurveda principles have not entered laboratories and only a handful of studies have identified pure components and molecular pathways for its life-enhancing effects. In the post-genomic era, genome-wide functional screenings for targets for diseases is the most recent and practical approach. We illustrate here the merger of ayurveda and functional genomics in a systems biology scenario that reveals the pathway analysis of crude and active components and inspire ayurveda practice for health benefits, disease prevention and therapeutics.

Show MeSH

Related in: MedlinePlus

Global topology of the network interactions among the components of the crude extract. Each box network identified by IPA based on the input gene list corresponding to the gene target of each HPLC purified component. Note, the centrality of the molecular network affected by the crude extract. This could indicate a synergism of all the components could lead to a convergence to that of the crude extract.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2311278&req=5

Figure 3: Global topology of the network interactions among the components of the crude extract. Each box network identified by IPA based on the input gene list corresponding to the gene target of each HPLC purified component. Note, the centrality of the molecular network affected by the crude extract. This could indicate a synergism of all the components could lead to a convergence to that of the crude extract.

Mentions: Thus, as it seems paradoxical that the sum of pathways for individual components would, on the contrary, yield to a lesser number compared with the crude extract, a global analysis of the interactome of the five components (wihtanone, withaferin A and three uncharacterized fractions) may provide a rational explanation. As shown in Fig. 3, a simplified representation of network-web showed that the crude extract from LASH occupy the central 'hub' position interconnecting all the pathways representing its individual components. This apparent 'design principle' implicates a special property of the crude extract since the individual components branch-off with robust yet low-connectivity networks, the crude extract maintained the essential few network hub that have the greatest overall effect on cell growth and proliferation. We hypothesize that the interaction between components of the crude extracts may either lead to a synergy of cell killing effects or neutralize the toxicity of each other. This could be significant to the greater appreciation of herbal preparation in mainstream medicine.


Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology.

Deocaris CC, Widodo N, Wadhwa R, Kaul SC - J Transl Med (2008)

Global topology of the network interactions among the components of the crude extract. Each box network identified by IPA based on the input gene list corresponding to the gene target of each HPLC purified component. Note, the centrality of the molecular network affected by the crude extract. This could indicate a synergism of all the components could lead to a convergence to that of the crude extract.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2311278&req=5

Figure 3: Global topology of the network interactions among the components of the crude extract. Each box network identified by IPA based on the input gene list corresponding to the gene target of each HPLC purified component. Note, the centrality of the molecular network affected by the crude extract. This could indicate a synergism of all the components could lead to a convergence to that of the crude extract.
Mentions: Thus, as it seems paradoxical that the sum of pathways for individual components would, on the contrary, yield to a lesser number compared with the crude extract, a global analysis of the interactome of the five components (wihtanone, withaferin A and three uncharacterized fractions) may provide a rational explanation. As shown in Fig. 3, a simplified representation of network-web showed that the crude extract from LASH occupy the central 'hub' position interconnecting all the pathways representing its individual components. This apparent 'design principle' implicates a special property of the crude extract since the individual components branch-off with robust yet low-connectivity networks, the crude extract maintained the essential few network hub that have the greatest overall effect on cell growth and proliferation. We hypothesize that the interaction between components of the crude extracts may either lead to a synergy of cell killing effects or neutralize the toxicity of each other. This could be significant to the greater appreciation of herbal preparation in mainstream medicine.

Bottom Line: Ayurveda is one of the ancient systems of health care of Indian origin.Although sheltered with long history and high trust, ayurveda principles have not entered laboratories and only a handful of studies have identified pure components and molecular pathways for its life-enhancing effects.We illustrate here the merger of ayurveda and functional genomics in a systems biology scenario that reveals the pathway analysis of crude and active components and inspire ayurveda practice for health benefits, disease prevention and therapeutics.

View Article: PubMed Central - HTML - PubMed

Affiliation: National Institute of Advanced Industrial Science & Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. custerd@biochem.taiiku.tsukuba.ac.jp

ABSTRACT
Ayurveda is one of the ancient systems of health care of Indian origin. Roughly translated into "Knowledge of life", it is based on the use of natural herbs and herb products for therapeutic measures to boost physical, mental, social and spiritual harmony and improve quality of life. Although sheltered with long history and high trust, ayurveda principles have not entered laboratories and only a handful of studies have identified pure components and molecular pathways for its life-enhancing effects. In the post-genomic era, genome-wide functional screenings for targets for diseases is the most recent and practical approach. We illustrate here the merger of ayurveda and functional genomics in a systems biology scenario that reveals the pathway analysis of crude and active components and inspire ayurveda practice for health benefits, disease prevention and therapeutics.

Show MeSH
Related in: MedlinePlus