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Endoscopic and histological features of the large intestine in patients with atopic dermatitis.

Arisawa T, Arisawa S, Yokoi T, Kuroda M, Hirata I, Nakano H - J Clin Biochem Nutr (2007)

Bottom Line: There were no changes after an antifungal therapy.Candida albicans was not detected in any of the subjects.In conclusion, patients with atopic dermatitis may have a predisposition to develop chronic inflammation of the large intestine.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Fujita Health University, School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.

ABSTRACT
Although atopic dermatitis is known to be closely associated with food antigens, the actual changes in the gastrointestinal tract have not been clarified. The aim of this study was to investigate the macroscopic and histological features of the large intestine in patients with atopic dermatitis. We studied 15 outpatients who had generalized atopic dermatitis. Eight non-dermatitis subjects of a similar age without inflammatory bowel disease were also enrolled as controls. Total colonoscopy, pathological evaluation of biopsy specimens, and detection of Candida albicans were performed in all subjects. Four patients were re-examined after 6 months of treatment with an antifungal drug. Among the 15 patients with atopic dermatitis, 4 patients had melanosis coli. On pathological examinations, prominent infiltration of eosinophils and fragmentation of granulocyte nuclei were observed. There were no changes after an antifungal therapy. In the patients with melanosis coli, lipofuscin deposits were observed in the lamina propria. Candida albicans was not detected in any of the subjects. In conclusion, patients with atopic dermatitis may have a predisposition to develop chronic inflammation of the large intestine.

No MeSH data available.


Related in: MedlinePlus

Histological scores. In the atopic dermatitis group, the scores for both eosinophil infiltration and fragmentation of granulocyte nuclei were significantly higher than in the control group. Values are shown as the mean ± SE. *: p<0.05.
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Figure 3: Histological scores. In the atopic dermatitis group, the scores for both eosinophil infiltration and fragmentation of granulocyte nuclei were significantly higher than in the control group. Values are shown as the mean ± SE. *: p<0.05.

Mentions: Table 2 summarized the results of histological examination. Eosinophil infiltration and granulocyte nuclear fragments were significantly more common in the atopic dermatitis group than the control group (both p<0.05, Figs. 2 and 3). There was no relationship between the peripheral blood eosinophil count and the extent of eosinophil infiltration into the colonic mucosa. In the patients with melanosis coli, lipofuscin deposits were also observed in the lamina propria (Fig. 3). The total IgE level showed no association with any of these histological findings. The histological changes did not improve in any of the 4 patient cases after treatment with an antifungal drug for 6 months, although skin eruptions were alleviated.


Endoscopic and histological features of the large intestine in patients with atopic dermatitis.

Arisawa T, Arisawa S, Yokoi T, Kuroda M, Hirata I, Nakano H - J Clin Biochem Nutr (2007)

Histological scores. In the atopic dermatitis group, the scores for both eosinophil infiltration and fragmentation of granulocyte nuclei were significantly higher than in the control group. Values are shown as the mean ± SE. *: p<0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2291501&req=5

Figure 3: Histological scores. In the atopic dermatitis group, the scores for both eosinophil infiltration and fragmentation of granulocyte nuclei were significantly higher than in the control group. Values are shown as the mean ± SE. *: p<0.05.
Mentions: Table 2 summarized the results of histological examination. Eosinophil infiltration and granulocyte nuclear fragments were significantly more common in the atopic dermatitis group than the control group (both p<0.05, Figs. 2 and 3). There was no relationship between the peripheral blood eosinophil count and the extent of eosinophil infiltration into the colonic mucosa. In the patients with melanosis coli, lipofuscin deposits were also observed in the lamina propria (Fig. 3). The total IgE level showed no association with any of these histological findings. The histological changes did not improve in any of the 4 patient cases after treatment with an antifungal drug for 6 months, although skin eruptions were alleviated.

Bottom Line: There were no changes after an antifungal therapy.Candida albicans was not detected in any of the subjects.In conclusion, patients with atopic dermatitis may have a predisposition to develop chronic inflammation of the large intestine.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Fujita Health University, School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.

ABSTRACT
Although atopic dermatitis is known to be closely associated with food antigens, the actual changes in the gastrointestinal tract have not been clarified. The aim of this study was to investigate the macroscopic and histological features of the large intestine in patients with atopic dermatitis. We studied 15 outpatients who had generalized atopic dermatitis. Eight non-dermatitis subjects of a similar age without inflammatory bowel disease were also enrolled as controls. Total colonoscopy, pathological evaluation of biopsy specimens, and detection of Candida albicans were performed in all subjects. Four patients were re-examined after 6 months of treatment with an antifungal drug. Among the 15 patients with atopic dermatitis, 4 patients had melanosis coli. On pathological examinations, prominent infiltration of eosinophils and fragmentation of granulocyte nuclei were observed. There were no changes after an antifungal therapy. In the patients with melanosis coli, lipofuscin deposits were observed in the lamina propria. Candida albicans was not detected in any of the subjects. In conclusion, patients with atopic dermatitis may have a predisposition to develop chronic inflammation of the large intestine.

No MeSH data available.


Related in: MedlinePlus