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Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples.

Ferreccio C, Corvalán A, Margozzini P, Viviani P, González C, Aguilera X, Gravitt PE - BMC Public Health (2008)

Bottom Line: High-risk and low-risk HPV rates were inversely correlated between the regions.High-risk HPV prevalence was highest among the youngest women, whereas low-risk HPV increased slightly with age.Self-obtained vaginal sampling is adequate for monitoring HPV in the community, for identifying high-risk areas, and for surveying the long term impact of interventions.

View Article: PubMed Central - HTML - PubMed

Affiliation: P. Universidad Católica de Chile, Escuela de Medicina, Santiago Chile. cferrec@med.puc.cl

ABSTRACT

Background: Chile has broad variations in weather, economics and population from the far desert north (Region 1) to the cold, icy south (Region 12). A home-based self-collected vaginal sampling was nested in the 2003 Chilean population-based health survey in order to explore the possibility of a type-specific geographical variation for human papillomavirus

Methods: The population was a national probability sample of people 17 years of age and over. Consenting women provided self-collected cervicovaginal swabs in universal collection media (UCM). DNA was extracted and typed to 37 HPV genotypes using PGMY consensus PCR and line blot assay. Weighted prevalence rates and adjusted OR were calculated.

Results: Of the 1,883 women participating in the health survey, 1,219 (64.7%) provided a cervicovaginal sample and in 1,110 (56.2% of participants and 66.5% of those eligible) the samples were adequate for analysis. Refusal rate was 16.9%. HPV prevalence was 29.2% (15.1% high-risk HPV and 14.1% low-risk HPV). Predominant high-risk types were HPV 16, 52, 51, 56 and 58. Predominant low-risk HPVs were HPV 84, CP6108, 62, 53 and 61. High-risk and low-risk HPV rates were inversely correlated between the regions. High-risk HPV prevalence was highest among the youngest women, whereas low-risk HPV increased slightly with age.

Conclusion: Self-obtained vaginal sampling is adequate for monitoring HPV in the community, for identifying high-risk areas, and for surveying the long term impact of interventions.

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Age prevalence of high-risk HPV in vaginal samples from the population. National Health Survey, Chile 2003.
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Figure 3: Age prevalence of high-risk HPV in vaginal samples from the population. National Health Survey, Chile 2003.

Mentions: High-risk HPV prevalence was highest in the younger age group (under 25 years old) and declined significantly with age (Figure 3). Low-risk HPV had a positive but not statistically significant increase with age (Figure 4). Single women had a higher prevalence of high-risk HPV infection (OR = 3.7 95% confidence interval (CI) 2.1–6.6) while women who were older (OR = 0.29, 95% CI; 0.1–0.8) and living in a rural area (OR = 0.25 95% CI 0.1–0.7) were significantly less likely to have prevalent high-risk HPV (Table 3). Ever having had a Papanicolaou was unrelated with either high-risk or low-risk HPV. We found no association between either high-risk or low-risk HPV and years of education. After multivariate adjustment, the only risk factors for low-risk HPV were being separated (OR = 2.1 95% CI 1.2–3.7) and residing in the southern regions (OR = 2.3 95% CI 1.4–3.7) (Table 3).


Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples.

Ferreccio C, Corvalán A, Margozzini P, Viviani P, González C, Aguilera X, Gravitt PE - BMC Public Health (2008)

Age prevalence of high-risk HPV in vaginal samples from the population. National Health Survey, Chile 2003.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2291464&req=5

Figure 3: Age prevalence of high-risk HPV in vaginal samples from the population. National Health Survey, Chile 2003.
Mentions: High-risk HPV prevalence was highest in the younger age group (under 25 years old) and declined significantly with age (Figure 3). Low-risk HPV had a positive but not statistically significant increase with age (Figure 4). Single women had a higher prevalence of high-risk HPV infection (OR = 3.7 95% confidence interval (CI) 2.1–6.6) while women who were older (OR = 0.29, 95% CI; 0.1–0.8) and living in a rural area (OR = 0.25 95% CI 0.1–0.7) were significantly less likely to have prevalent high-risk HPV (Table 3). Ever having had a Papanicolaou was unrelated with either high-risk or low-risk HPV. We found no association between either high-risk or low-risk HPV and years of education. After multivariate adjustment, the only risk factors for low-risk HPV were being separated (OR = 2.1 95% CI 1.2–3.7) and residing in the southern regions (OR = 2.3 95% CI 1.4–3.7) (Table 3).

Bottom Line: High-risk and low-risk HPV rates were inversely correlated between the regions.High-risk HPV prevalence was highest among the youngest women, whereas low-risk HPV increased slightly with age.Self-obtained vaginal sampling is adequate for monitoring HPV in the community, for identifying high-risk areas, and for surveying the long term impact of interventions.

View Article: PubMed Central - HTML - PubMed

Affiliation: P. Universidad Católica de Chile, Escuela de Medicina, Santiago Chile. cferrec@med.puc.cl

ABSTRACT

Background: Chile has broad variations in weather, economics and population from the far desert north (Region 1) to the cold, icy south (Region 12). A home-based self-collected vaginal sampling was nested in the 2003 Chilean population-based health survey in order to explore the possibility of a type-specific geographical variation for human papillomavirus

Methods: The population was a national probability sample of people 17 years of age and over. Consenting women provided self-collected cervicovaginal swabs in universal collection media (UCM). DNA was extracted and typed to 37 HPV genotypes using PGMY consensus PCR and line blot assay. Weighted prevalence rates and adjusted OR were calculated.

Results: Of the 1,883 women participating in the health survey, 1,219 (64.7%) provided a cervicovaginal sample and in 1,110 (56.2% of participants and 66.5% of those eligible) the samples were adequate for analysis. Refusal rate was 16.9%. HPV prevalence was 29.2% (15.1% high-risk HPV and 14.1% low-risk HPV). Predominant high-risk types were HPV 16, 52, 51, 56 and 58. Predominant low-risk HPVs were HPV 84, CP6108, 62, 53 and 61. High-risk and low-risk HPV rates were inversely correlated between the regions. High-risk HPV prevalence was highest among the youngest women, whereas low-risk HPV increased slightly with age.

Conclusion: Self-obtained vaginal sampling is adequate for monitoring HPV in the community, for identifying high-risk areas, and for surveying the long term impact of interventions.

Show MeSH
Related in: MedlinePlus