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The effect of Korean pine nut oil (PinnoThin) on food intake, feeding behaviour and appetite: a double-blind placebo-controlled trial.

Hughes GM, Boyland EJ, Williams NJ, Mennen L, Scott C, Kirkham TC, Harrold JA, Keizer HG, Halford JC - Lipids Health Dis (2008)

Bottom Line: Certain free fatty acids have been shown to have potent effects on food intake and self-reported changes in appetite; effects associated with increases in the release of endogenous cholecystokinin (CCK) and glucagon like peptide-1 (GLP-1).No significant effect of PinnoThin on macronutrient intake or ratings of appetite were observed.Given the recent data showing that the TG form of PinnoThin may also reduce appetite by increasing CCK release, the lack of any effect of the TG form found in this study could be attributed to the timing of the dosing regime.

View Article: PubMed Central - HTML - PubMed

Affiliation: School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool, L69 7ZA, UK. georgina.hughes@liverpool.ac.uk

ABSTRACT
Certain free fatty acids have been shown to have potent effects on food intake and self-reported changes in appetite; effects associated with increases in the release of endogenous cholecystokinin (CCK) and glucagon like peptide-1 (GLP-1). In the current study, the effects of a Korean pine nut oil product, PinnoThin, at doses 2 g, 4 g and 6 g triglyceride (TG) and 2 g free fatty acid (FFA), on food intake and appetite were examined in a cross-over double-blind placebo-controlled randomised counter-balanced design in 42 overweight female volunteers. 2 g FFA PinnoThin, given 30 minutes prior to an ad-libitum buffet test lunch, significantly reduced food intake (gram) by 9% (F(4,164) = 2.637, p = 0.036) compared to olive oil control. No significant effect of PinnoThin on macronutrient intake or ratings of appetite were observed. Given the recent data showing that the TG form of PinnoThin may also reduce appetite by increasing CCK release, the lack of any effect of the TG form found in this study could be attributed to the timing of the dosing regime. Collectively, these data suggest that PinnoThin may exert satiating effects consistent with its known action on CCK and GLP-1 release, and previously observed effects on self-reported appetite ratings.

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Related in: MedlinePlus

Total enquiries, participants screened and recruited to study.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2289823&req=5

Figure 1: Total enquiries, participants screened and recruited to study.

Mentions: The study commenced in June 2006 and was completed in February 2007. In total, 45 women were enrolled onto the study. Of the 45 enrolled, 42 participants completed all five conditions. One participant completed one morning and lunch session of one visit and withdrew due to unrelated illness; one participant completed one full visit but withdrew from the study due to illness, the cause of which was unascertained; and one participant completed two visits before withdrawing due to childminding problems. Figure 1 shows details of the number of enquiries, participants screened and outcome. The demographic (age), and anthropometric (weight, height, BMI) characteristics of the completing participants, together with the screening measure scores are shown in Table 1.


The effect of Korean pine nut oil (PinnoThin) on food intake, feeding behaviour and appetite: a double-blind placebo-controlled trial.

Hughes GM, Boyland EJ, Williams NJ, Mennen L, Scott C, Kirkham TC, Harrold JA, Keizer HG, Halford JC - Lipids Health Dis (2008)

Total enquiries, participants screened and recruited to study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2289823&req=5

Figure 1: Total enquiries, participants screened and recruited to study.
Mentions: The study commenced in June 2006 and was completed in February 2007. In total, 45 women were enrolled onto the study. Of the 45 enrolled, 42 participants completed all five conditions. One participant completed one morning and lunch session of one visit and withdrew due to unrelated illness; one participant completed one full visit but withdrew from the study due to illness, the cause of which was unascertained; and one participant completed two visits before withdrawing due to childminding problems. Figure 1 shows details of the number of enquiries, participants screened and outcome. The demographic (age), and anthropometric (weight, height, BMI) characteristics of the completing participants, together with the screening measure scores are shown in Table 1.

Bottom Line: Certain free fatty acids have been shown to have potent effects on food intake and self-reported changes in appetite; effects associated with increases in the release of endogenous cholecystokinin (CCK) and glucagon like peptide-1 (GLP-1).No significant effect of PinnoThin on macronutrient intake or ratings of appetite were observed.Given the recent data showing that the TG form of PinnoThin may also reduce appetite by increasing CCK release, the lack of any effect of the TG form found in this study could be attributed to the timing of the dosing regime.

View Article: PubMed Central - HTML - PubMed

Affiliation: School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool, L69 7ZA, UK. georgina.hughes@liverpool.ac.uk

ABSTRACT
Certain free fatty acids have been shown to have potent effects on food intake and self-reported changes in appetite; effects associated with increases in the release of endogenous cholecystokinin (CCK) and glucagon like peptide-1 (GLP-1). In the current study, the effects of a Korean pine nut oil product, PinnoThin, at doses 2 g, 4 g and 6 g triglyceride (TG) and 2 g free fatty acid (FFA), on food intake and appetite were examined in a cross-over double-blind placebo-controlled randomised counter-balanced design in 42 overweight female volunteers. 2 g FFA PinnoThin, given 30 minutes prior to an ad-libitum buffet test lunch, significantly reduced food intake (gram) by 9% (F(4,164) = 2.637, p = 0.036) compared to olive oil control. No significant effect of PinnoThin on macronutrient intake or ratings of appetite were observed. Given the recent data showing that the TG form of PinnoThin may also reduce appetite by increasing CCK release, the lack of any effect of the TG form found in this study could be attributed to the timing of the dosing regime. Collectively, these data suggest that PinnoThin may exert satiating effects consistent with its known action on CCK and GLP-1 release, and previously observed effects on self-reported appetite ratings.

Show MeSH
Related in: MedlinePlus