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Treatment of osteonecrosis of the femoral head using autologous cultured osteoblasts: a case report.

Kim SJ, Bahk WJ, Chang CH, Jang JD, Suhl KH - J Med Case Rep (2008)

Bottom Line: Osteonecrosis of the femoral head is a progressive disease that leads to femoral head collapse and osteoarthritis.We present the case of a patient with bilateral osteonecrosis of the femoral head treated with autologous cultured osteoblast injection.Although our experience is limited to one patient, autologous cultured osteoblast transplantation appears to be effective for treating the osteonecrosis of femoral head.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Orthopedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea. peter@catholic.ac.kr

ABSTRACT

Introduction: Osteonecrosis of the femoral head is a progressive disease that leads to femoral head collapse and osteoarthritis. Our goal in treating osteonecrosis is to preserve, not to replace, the femoral head.

Case presentation: We present the case of a patient with bilateral osteonecrosis of the femoral head treated with autologous cultured osteoblast injection.

Conclusion: Although our experience is limited to one patient, autologous cultured osteoblast transplantation appears to be effective for treating the osteonecrosis of femoral head.

No MeSH data available.


Related in: MedlinePlus

A) Preoperative AP radiograph of both hips shows round cystic change with a sclerotic rim and no femoral head flattening in either femoral head. B) Superior delineations of the necrotic areas in both femoral heads are seen on a T1-weighted, coronal, preoperative MRI image. C) Post-operative CT image of both femoral heads shows core decompression sites in both femoral heads and allograft impaction of the left femoral head. D) Both hip AP radiographs, E) MRI and F) CT images, were taken five years following surgery.
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Figure 1: A) Preoperative AP radiograph of both hips shows round cystic change with a sclerotic rim and no femoral head flattening in either femoral head. B) Superior delineations of the necrotic areas in both femoral heads are seen on a T1-weighted, coronal, preoperative MRI image. C) Post-operative CT image of both femoral heads shows core decompression sites in both femoral heads and allograft impaction of the left femoral head. D) Both hip AP radiographs, E) MRI and F) CT images, were taken five years following surgery.

Mentions: A 31-year old man was admitted with symptoms of acute joint pain of three weeks' duration in both hips. The patient had no specific past history of disease and his laboratory findings were normal. Plain radiographs (Fig. 1A) and MR examination (Fig. 1B) revealed Ficat II osteonecrosis of both femoral heads. The left femoral head was treated by allograft immediately after core decompression, while the right side was treated by injection of autologous cultured osteoblasts for four weeks after the core decompression (Fig. 1C).


Treatment of osteonecrosis of the femoral head using autologous cultured osteoblasts: a case report.

Kim SJ, Bahk WJ, Chang CH, Jang JD, Suhl KH - J Med Case Rep (2008)

A) Preoperative AP radiograph of both hips shows round cystic change with a sclerotic rim and no femoral head flattening in either femoral head. B) Superior delineations of the necrotic areas in both femoral heads are seen on a T1-weighted, coronal, preoperative MRI image. C) Post-operative CT image of both femoral heads shows core decompression sites in both femoral heads and allograft impaction of the left femoral head. D) Both hip AP radiographs, E) MRI and F) CT images, were taken five years following surgery.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2279138&req=5

Figure 1: A) Preoperative AP radiograph of both hips shows round cystic change with a sclerotic rim and no femoral head flattening in either femoral head. B) Superior delineations of the necrotic areas in both femoral heads are seen on a T1-weighted, coronal, preoperative MRI image. C) Post-operative CT image of both femoral heads shows core decompression sites in both femoral heads and allograft impaction of the left femoral head. D) Both hip AP radiographs, E) MRI and F) CT images, were taken five years following surgery.
Mentions: A 31-year old man was admitted with symptoms of acute joint pain of three weeks' duration in both hips. The patient had no specific past history of disease and his laboratory findings were normal. Plain radiographs (Fig. 1A) and MR examination (Fig. 1B) revealed Ficat II osteonecrosis of both femoral heads. The left femoral head was treated by allograft immediately after core decompression, while the right side was treated by injection of autologous cultured osteoblasts for four weeks after the core decompression (Fig. 1C).

Bottom Line: Osteonecrosis of the femoral head is a progressive disease that leads to femoral head collapse and osteoarthritis.We present the case of a patient with bilateral osteonecrosis of the femoral head treated with autologous cultured osteoblast injection.Although our experience is limited to one patient, autologous cultured osteoblast transplantation appears to be effective for treating the osteonecrosis of femoral head.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Orthopedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea. peter@catholic.ac.kr

ABSTRACT

Introduction: Osteonecrosis of the femoral head is a progressive disease that leads to femoral head collapse and osteoarthritis. Our goal in treating osteonecrosis is to preserve, not to replace, the femoral head.

Case presentation: We present the case of a patient with bilateral osteonecrosis of the femoral head treated with autologous cultured osteoblast injection.

Conclusion: Although our experience is limited to one patient, autologous cultured osteoblast transplantation appears to be effective for treating the osteonecrosis of femoral head.

No MeSH data available.


Related in: MedlinePlus