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Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment.

He T, Kirk P, Firmin DN, Lam WM, Chu WC, Au WY, Chan GC, Tan RS, Ng I, Biceroglu S, Aydinok Y, Fogel MA, Cohen AR, Pennell DJ - J Cardiovasc Magn Reson (2008)

Bottom Line: The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms.The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms.The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility.

View Article: PubMed Central - HTML - PubMed

Affiliation: National Heart and Lung Institute, Imperial College London, UK. h.taigang@rbht.nhs.uk

ABSTRACT

Background: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated.

Methods and results: The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this sequence, 5-10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34) and all were rescanned within one month at the standardization centre in London (intersite reproducibility). The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms.

Conclusion: The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia.

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Assessment of intersite reproducibility between local centers and the standard center in London (n = 34). A) Bland-Altman plot of the myocardial T2 values obtained locally and at London within a month, with the 95% confidence intervals shown as a dotted line. B) Scatter plot of the myocardial T2 values obtained locally and at London within a month. The diagonal line shows the line of identity.
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Figure 2: Assessment of intersite reproducibility between local centers and the standard center in London (n = 34). A) Bland-Altman plot of the myocardial T2 values obtained locally and at London within a month, with the 95% confidence intervals shown as a dotted line. B) Scatter plot of the myocardial T2 values obtained locally and at London within a month. The diagonal line shows the line of identity.

Mentions: The mean difference was -0.07 ms and the CoV for intersite reproducibility was found to be 5.2%. These values were similar to those of local interstudy reproducibility mentioned above. This demonstrates good agreement between the standard center scanner and the local scanners at each center and no bias was found (Figure 2).


Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment.

He T, Kirk P, Firmin DN, Lam WM, Chu WC, Au WY, Chan GC, Tan RS, Ng I, Biceroglu S, Aydinok Y, Fogel MA, Cohen AR, Pennell DJ - J Cardiovasc Magn Reson (2008)

Assessment of intersite reproducibility between local centers and the standard center in London (n = 34). A) Bland-Altman plot of the myocardial T2 values obtained locally and at London within a month, with the 95% confidence intervals shown as a dotted line. B) Scatter plot of the myocardial T2 values obtained locally and at London within a month. The diagonal line shows the line of identity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2279115&req=5

Figure 2: Assessment of intersite reproducibility between local centers and the standard center in London (n = 34). A) Bland-Altman plot of the myocardial T2 values obtained locally and at London within a month, with the 95% confidence intervals shown as a dotted line. B) Scatter plot of the myocardial T2 values obtained locally and at London within a month. The diagonal line shows the line of identity.
Mentions: The mean difference was -0.07 ms and the CoV for intersite reproducibility was found to be 5.2%. These values were similar to those of local interstudy reproducibility mentioned above. This demonstrates good agreement between the standard center scanner and the local scanners at each center and no bias was found (Figure 2).

Bottom Line: The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms.The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms.The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility.

View Article: PubMed Central - HTML - PubMed

Affiliation: National Heart and Lung Institute, Imperial College London, UK. h.taigang@rbht.nhs.uk

ABSTRACT

Background: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated.

Methods and results: The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this sequence, 5-10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34) and all were rescanned within one month at the standardization centre in London (intersite reproducibility). The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms.

Conclusion: The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia.

Show MeSH
Related in: MedlinePlus