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Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents.

Chel V, Wijnhoven HA, Smit JH, Ooms M, Lips P - Osteoporos Int (2007)

Bottom Line: Bone turnover markers did not decrease.Calcium supplementation had no effect on serum PTH and bone turnover.Daily vitamin D was more effective than weekly, and monthly administration was the least effective.

View Article: PubMed Central - PubMed

Affiliation: Verpleeghuis Marienhave, Warmond, The Netherlands.

ABSTRACT

Unlabelled: The effect of equivalent oral doses of vitamin D3 600 IU/day, 4200 IU/week and 18,000 IU/month on vitamin D status was compared in a randomized clinical trial in nursing home residents. A daily dose was more effective than a weekly dose, and a monthly dose was the least effective.

Introduction: It is assumed that equivalent daily, weekly or monthly doses of vitamin D3 equally influence vitamin D status. This was investigated in a randomized clinical trial in nursing home residents.

Methods: The study was performed in ten nursing homes including 338 subjects (76 male and 262 female), with a mean age of 84 (+/- SD 6.3 years). They received oral vitamin D3 either 600 IU/day, or 4200 IU/week, or 18,000 IU/month or placebo. After 4 months, calcium was added during 2 weeks, 320 mg/day or 640 mg/day or placebo.

Outcome: serum levels of 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and bone turnover markers. Statistical approach: linear multilevel analysis.

Results: At baseline, mean serum 25(OH)D was 25.0 nmol/L (SD 10.9), and in 98%, it was lower than 50 nmol/L. After 4 months, mean serum 25(OH)D levels increased to 62.5 nmol/L (after daily vitamin D3 69.9 nmol/L, weekly 67.2 nmol/L and monthly 53.1 nmol/L, P < 0.001 between groups). Median serum PTH levels decreased by 23% (p < 0.001). Bone turnover markers did not decrease. Calcium supplementation had no effect on serum PTH and bone turnover.

Conclusion: Daily vitamin D was more effective than weekly, and monthly administration was the least effective.

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Flow diagram of progress through the randomized clinical trial of vitamin D supplementation followed by the randomized clinical trial of calcium supplementation
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Fig1: Flow diagram of progress through the randomized clinical trial of vitamin D supplementation followed by the randomized clinical trial of calcium supplementation

Mentions: Figure 1 shows the trial schedule as well as the results of the randomisation procedure of both the vitamin D and the calcium intervention. Of the 341 participants originally enrolled, three were enrolled incorrectly because of hypercalcemia (corrected serum calcium: 2.69; 2.83; and 2.85), leaving 338 participants eligible for the study.Fig. 1


Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents.

Chel V, Wijnhoven HA, Smit JH, Ooms M, Lips P - Osteoporos Int (2007)

Flow diagram of progress through the randomized clinical trial of vitamin D supplementation followed by the randomized clinical trial of calcium supplementation
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2277446&req=5

Fig1: Flow diagram of progress through the randomized clinical trial of vitamin D supplementation followed by the randomized clinical trial of calcium supplementation
Mentions: Figure 1 shows the trial schedule as well as the results of the randomisation procedure of both the vitamin D and the calcium intervention. Of the 341 participants originally enrolled, three were enrolled incorrectly because of hypercalcemia (corrected serum calcium: 2.69; 2.83; and 2.85), leaving 338 participants eligible for the study.Fig. 1

Bottom Line: Bone turnover markers did not decrease.Calcium supplementation had no effect on serum PTH and bone turnover.Daily vitamin D was more effective than weekly, and monthly administration was the least effective.

View Article: PubMed Central - PubMed

Affiliation: Verpleeghuis Marienhave, Warmond, The Netherlands.

ABSTRACT

Unlabelled: The effect of equivalent oral doses of vitamin D3 600 IU/day, 4200 IU/week and 18,000 IU/month on vitamin D status was compared in a randomized clinical trial in nursing home residents. A daily dose was more effective than a weekly dose, and a monthly dose was the least effective.

Introduction: It is assumed that equivalent daily, weekly or monthly doses of vitamin D3 equally influence vitamin D status. This was investigated in a randomized clinical trial in nursing home residents.

Methods: The study was performed in ten nursing homes including 338 subjects (76 male and 262 female), with a mean age of 84 (+/- SD 6.3 years). They received oral vitamin D3 either 600 IU/day, or 4200 IU/week, or 18,000 IU/month or placebo. After 4 months, calcium was added during 2 weeks, 320 mg/day or 640 mg/day or placebo.

Outcome: serum levels of 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and bone turnover markers. Statistical approach: linear multilevel analysis.

Results: At baseline, mean serum 25(OH)D was 25.0 nmol/L (SD 10.9), and in 98%, it was lower than 50 nmol/L. After 4 months, mean serum 25(OH)D levels increased to 62.5 nmol/L (after daily vitamin D3 69.9 nmol/L, weekly 67.2 nmol/L and monthly 53.1 nmol/L, P < 0.001 between groups). Median serum PTH levels decreased by 23% (p < 0.001). Bone turnover markers did not decrease. Calcium supplementation had no effect on serum PTH and bone turnover.

Conclusion: Daily vitamin D was more effective than weekly, and monthly administration was the least effective.

Show MeSH