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The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma.

Feller L, Masipa J, Wood N, Raubenheimer E, Lemmer J - AIDS Res Ther (2008)

Bottom Line: The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial.The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported.Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria, South Africa. lfeller@medunsa.ac.za

ABSTRACT

Background: Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable.

Results and conclusion: Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.

No MeSH data available.


Related in: MedlinePlus

Oedema of the face. Note the pronounced periorbital oedema.
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Figure 6: Oedema of the face. Note the pronounced periorbital oedema.

Mentions: A 55-year old HIV-seropositive man with a CD4+ T cell count of 12 × 106/l and CD4+ T cell and a percentage of total lymphocytes of 2.11%, had extensive cutaneous and oral lesions as well as pronounced oedema of the face (Fig 6), and the lower extremities.


The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma.

Feller L, Masipa J, Wood N, Raubenheimer E, Lemmer J - AIDS Res Ther (2008)

Oedema of the face. Note the pronounced periorbital oedema.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2275292&req=5

Figure 6: Oedema of the face. Note the pronounced periorbital oedema.
Mentions: A 55-year old HIV-seropositive man with a CD4+ T cell count of 12 × 106/l and CD4+ T cell and a percentage of total lymphocytes of 2.11%, had extensive cutaneous and oral lesions as well as pronounced oedema of the face (Fig 6), and the lower extremities.

Bottom Line: The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial.The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported.Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria, South Africa. lfeller@medunsa.ac.za

ABSTRACT

Background: Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable.

Results and conclusion: Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.

No MeSH data available.


Related in: MedlinePlus