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The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma.

Feller L, Masipa J, Wood N, Raubenheimer E, Lemmer J - AIDS Res Ther (2008)

Bottom Line: The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial.The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported.Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.

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Affiliation: Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria, South Africa. lfeller@medunsa.ac.za

ABSTRACT

Background: Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable.

Results and conclusion: Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.

No MeSH data available.


Related in: MedlinePlus

Multifocal purple-red maculo-papular KS lesions on the palate. Note the pseudomembranous candidiasis (arrow).
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Figure 3: Multifocal purple-red maculo-papular KS lesions on the palate. Note the pseudomembranous candidiasis (arrow).

Mentions: A 28-year-old black male with an unremarkable medical history presented with numerous nodules on the face (Fig 1), and with multifocal, purple-red, maculo-papular lesions on the gingivae (Fig 2), and on the hard palate (Fig 3). The patient reported that the facial and intra-oral lesions had appeared concurrently three months prior to our examination.


The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma.

Feller L, Masipa J, Wood N, Raubenheimer E, Lemmer J - AIDS Res Ther (2008)

Multifocal purple-red maculo-papular KS lesions on the palate. Note the pseudomembranous candidiasis (arrow).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2275292&req=5

Figure 3: Multifocal purple-red maculo-papular KS lesions on the palate. Note the pseudomembranous candidiasis (arrow).
Mentions: A 28-year-old black male with an unremarkable medical history presented with numerous nodules on the face (Fig 1), and with multifocal, purple-red, maculo-papular lesions on the gingivae (Fig 2), and on the hard palate (Fig 3). The patient reported that the facial and intra-oral lesions had appeared concurrently three months prior to our examination.

Bottom Line: The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial.The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported.Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Periodontology and Oral Medicine, University of Limpopo School of Dentistry, Pretoria, South Africa. lfeller@medunsa.ac.za

ABSTRACT

Background: Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable.

Results and conclusion: Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.

No MeSH data available.


Related in: MedlinePlus