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Abdominal ultrasonography in HIV/AIDS patients in southwestern Nigeria.

Obajimi MO, Atalabi MO, Ogbole GI, Adeniji-Sofoluwe AT, Agunloye AM, Adekanmi AJ, Osuagwu YU, Olarinoye SA, Olusola-Bello MA, Ogunseyinde AO, Aken'Ova YA, Adewole IF - BMC Med Imaging (2008)

Bottom Line: Compared with the HIV-negative individuals, the HIV+ group of patients had a significantly higher proportion of splenomegaly (13.5% vs. 7.7%; p < 0.01), lymphadenopathy (2.0% vs. 1.3%; p < 0.70), and renal abnormalities (8.4% vs. 3.8%; p < 0.02).There were significantly fewer gallstones in the HIV+ group (1.4% vs. 5.1%; p < 0.01).Its accuracy and sensitivity may be much improved with clinico-pathologic correlation which may not be readily available in developing countries; further studies may provide this much needed diagnostic algorithms.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Radiology, University College Hospital, Ibadan, Nigeria. millieobaj@yahoo.com

ABSTRACT

Background: Though the major target of the HIV-virus is the immune system, the frequency of abdominal disorders in HIV/AIDS patients has been reported to be second only to pulmonary disease. These abdominal manifestations may be on the increase as the use of antiretroviral therapy has increased life expectancy and improved quality of life. Ultrasonography is an easy to perform, non invasive, inexpensive and safe imaging technique that is invaluable in Africa where AIDS is most prevalent and where sophisticated diagnostic tools are not readily available.

Purpose: To describe the findings and evaluate the clinical utility of abdominal ultrasonography in HIV/AIDS patients in Ibadan, Nigeria

Methods: A Prospective evaluation of the abdominal ultrasonography of 391 HIV-positive patients as well as 391 age and sex-matched HIV-negative patients were carried out at the University College Hospital, Ibadan.

Results: Of the 391 cases studied, 260 (66.5%) were females; the mean age was 38.02 years, (range 15-66 years). The disease was most prevalent in the 4th decade with an incidence of 40.4%. Compared with the HIV-negative individuals, the HIV+ group of patients had a significantly higher proportion of splenomegaly (13.5% vs. 7.7%; p < 0.01), lymphadenopathy (2.0% vs. 1.3%; p < 0.70), and renal abnormalities (8.4% vs. 3.8%; p < 0.02). There were no differences in hepatic and pancreatic abnormalities between the HIV+ and HIV- groups. There were significantly fewer gallstones in the HIV+ group (1.4% vs. 5.1%; p < 0.01).

Conclusion: AIDS is a multi-systemic disease and its demographic and clinical pattern remains the same globally. Ultrasonography is optimally suited for its clinical management especially in Africa. Its accuracy and sensitivity may be much improved with clinico-pathologic correlation which may not be readily available in developing countries; further studies may provide this much needed diagnostic algorithms.

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Longitudinal sonogram of liver showing hepatomegaly and increased parenchymal echogenicity with posterior shadowing (*) compatible with fatty infiltration.
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Figure 1: Longitudinal sonogram of liver showing hepatomegaly and increased parenchymal echogenicity with posterior shadowing (*) compatible with fatty infiltration.

Mentions: Enlargement of the liver was also not significantly different in both groups: 52(13.3%) in cases versus 58(14.8%) in controls, these patients showed mostly non specific findings such as high parenchyma echogenicity compatible with fatty infiltration of the liver (Fig. 1). Evidence of cholelithiasis was noted in 6(1.5%) HIV+ cases but was significantly more in the control group, being present in 20 of 391(5.1%) patients (p < 0.01). Extrahepatic bile duct dilatation was also noted in 10 of 391 (2.6%) cases with a mean of 4.28 ± 1.18 mm. The width of the common bile duct ranged from 1.0 to 8.6 mm among HIV+ cases and 1.0 to 6.5 mm among the control group. No extrahepatic bile duct dilatation was recorded in the control group.


Abdominal ultrasonography in HIV/AIDS patients in southwestern Nigeria.

Obajimi MO, Atalabi MO, Ogbole GI, Adeniji-Sofoluwe AT, Agunloye AM, Adekanmi AJ, Osuagwu YU, Olarinoye SA, Olusola-Bello MA, Ogunseyinde AO, Aken'Ova YA, Adewole IF - BMC Med Imaging (2008)

Longitudinal sonogram of liver showing hepatomegaly and increased parenchymal echogenicity with posterior shadowing (*) compatible with fatty infiltration.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2275264&req=5

Figure 1: Longitudinal sonogram of liver showing hepatomegaly and increased parenchymal echogenicity with posterior shadowing (*) compatible with fatty infiltration.
Mentions: Enlargement of the liver was also not significantly different in both groups: 52(13.3%) in cases versus 58(14.8%) in controls, these patients showed mostly non specific findings such as high parenchyma echogenicity compatible with fatty infiltration of the liver (Fig. 1). Evidence of cholelithiasis was noted in 6(1.5%) HIV+ cases but was significantly more in the control group, being present in 20 of 391(5.1%) patients (p < 0.01). Extrahepatic bile duct dilatation was also noted in 10 of 391 (2.6%) cases with a mean of 4.28 ± 1.18 mm. The width of the common bile duct ranged from 1.0 to 8.6 mm among HIV+ cases and 1.0 to 6.5 mm among the control group. No extrahepatic bile duct dilatation was recorded in the control group.

Bottom Line: Compared with the HIV-negative individuals, the HIV+ group of patients had a significantly higher proportion of splenomegaly (13.5% vs. 7.7%; p < 0.01), lymphadenopathy (2.0% vs. 1.3%; p < 0.70), and renal abnormalities (8.4% vs. 3.8%; p < 0.02).There were significantly fewer gallstones in the HIV+ group (1.4% vs. 5.1%; p < 0.01).Its accuracy and sensitivity may be much improved with clinico-pathologic correlation which may not be readily available in developing countries; further studies may provide this much needed diagnostic algorithms.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Radiology, University College Hospital, Ibadan, Nigeria. millieobaj@yahoo.com

ABSTRACT

Background: Though the major target of the HIV-virus is the immune system, the frequency of abdominal disorders in HIV/AIDS patients has been reported to be second only to pulmonary disease. These abdominal manifestations may be on the increase as the use of antiretroviral therapy has increased life expectancy and improved quality of life. Ultrasonography is an easy to perform, non invasive, inexpensive and safe imaging technique that is invaluable in Africa where AIDS is most prevalent and where sophisticated diagnostic tools are not readily available.

Purpose: To describe the findings and evaluate the clinical utility of abdominal ultrasonography in HIV/AIDS patients in Ibadan, Nigeria

Methods: A Prospective evaluation of the abdominal ultrasonography of 391 HIV-positive patients as well as 391 age and sex-matched HIV-negative patients were carried out at the University College Hospital, Ibadan.

Results: Of the 391 cases studied, 260 (66.5%) were females; the mean age was 38.02 years, (range 15-66 years). The disease was most prevalent in the 4th decade with an incidence of 40.4%. Compared with the HIV-negative individuals, the HIV+ group of patients had a significantly higher proportion of splenomegaly (13.5% vs. 7.7%; p < 0.01), lymphadenopathy (2.0% vs. 1.3%; p < 0.70), and renal abnormalities (8.4% vs. 3.8%; p < 0.02). There were no differences in hepatic and pancreatic abnormalities between the HIV+ and HIV- groups. There were significantly fewer gallstones in the HIV+ group (1.4% vs. 5.1%; p < 0.01).

Conclusion: AIDS is a multi-systemic disease and its demographic and clinical pattern remains the same globally. Ultrasonography is optimally suited for its clinical management especially in Africa. Its accuracy and sensitivity may be much improved with clinico-pathologic correlation which may not be readily available in developing countries; further studies may provide this much needed diagnostic algorithms.

Show MeSH
Related in: MedlinePlus