Limits...
Sickle cell nephropathy with diffuse proliferative lupus nephritis: a case report.

Kanodia KV, Vanikar AV, Goplani KR, Gupta SB, Trivedi HL - Diagn Pathol (2008)

Bottom Line: Her biopsy revealed SCN with DPLN.She is on maintenance hemodialysis after 2 months of diagnosis.DPLN with SCN is a rare entity with poor prognosis, which may be overlooked and needs aggressive management.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Laboratory Medicine and Transfusion Services, and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases and Research Centre and Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India. kamalkanodia@yahoo.com

ABSTRACT

Background: Sickle cell nephropathy (SCN) is an important cause of mortality in patients with sickle cell disease. SCA with systemic lupus erythematosus (SLE) is known in children and less common in adults, however diffuse proliferative lupus nephritis (DPLN) with SCN has rarely been reported in adults. It requires early diagnosis and aggressive management.

Case presentation: We present here a 35 years old lady with sickle cell disease who presented with edema, dyspnoea on exertion, pyuria and had raised s. creatinine of 7 mg%. Her biopsy revealed SCN with DPLN. She is on maintenance hemodialysis after 2 months of diagnosis.

Conclusion: DPLN with SCN is a rare entity with poor prognosis, which may be overlooked and needs aggressive management.

No MeSH data available.


Related in: MedlinePlus

Haemoglobin variant study suggestive of HbSA.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2275218&req=5

Figure 4: Haemoglobin variant study suggestive of HbSA.

Mentions: Hemoglobin variant study using High Performance Liquid Chromatography (d-10, Biorad, USA) was performed 5 days after transfusion which showed HbSA of 6.9% (Figure 4).


Sickle cell nephropathy with diffuse proliferative lupus nephritis: a case report.

Kanodia KV, Vanikar AV, Goplani KR, Gupta SB, Trivedi HL - Diagn Pathol (2008)

Haemoglobin variant study suggestive of HbSA.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2275218&req=5

Figure 4: Haemoglobin variant study suggestive of HbSA.
Mentions: Hemoglobin variant study using High Performance Liquid Chromatography (d-10, Biorad, USA) was performed 5 days after transfusion which showed HbSA of 6.9% (Figure 4).

Bottom Line: Her biopsy revealed SCN with DPLN.She is on maintenance hemodialysis after 2 months of diagnosis.DPLN with SCN is a rare entity with poor prognosis, which may be overlooked and needs aggressive management.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Laboratory Medicine and Transfusion Services, and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases and Research Centre and Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India. kamalkanodia@yahoo.com

ABSTRACT

Background: Sickle cell nephropathy (SCN) is an important cause of mortality in patients with sickle cell disease. SCA with systemic lupus erythematosus (SLE) is known in children and less common in adults, however diffuse proliferative lupus nephritis (DPLN) with SCN has rarely been reported in adults. It requires early diagnosis and aggressive management.

Case presentation: We present here a 35 years old lady with sickle cell disease who presented with edema, dyspnoea on exertion, pyuria and had raised s. creatinine of 7 mg%. Her biopsy revealed SCN with DPLN. She is on maintenance hemodialysis after 2 months of diagnosis.

Conclusion: DPLN with SCN is a rare entity with poor prognosis, which may be overlooked and needs aggressive management.

No MeSH data available.


Related in: MedlinePlus