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Weekly full-dose gemcitabine and single-dose cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer.

Hong SP, Park JY, Jeon TJ, Bang S, Park SW, Chung JB, Park MS, Seong J, Lee WJ, Song SY - Br. J. Cancer (2008)

Bottom Line: Overall survival was significantly longer in the low baseline CA19-9 group and therapeutic responders.Toxicities were tolerable and successfully managed by conservative treatments.The therapeutic scheme of a weekly full dose of gemcitabine and a single dose of cisplatin combined with external radiation is effective and might prolong the survival of patients with locally advanced pancreatic cancer.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
The aim of this study was to evaluate the efficacy and the toxicity of a full dose of gemcitabine and a single dose of cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer. Forty-one patients with locally advanced pancreatic cancer were enrolled. Patients received gemcitabine (1000 mg m(-2) on days 1, 8, 15, 29, and 36) and cisplatin (70 mg m(-2) on days 1 and 29) with concurrent radiotherapy (45 Gy in 25 fractions). Treatment was completed in 38 out of 41 patients (92.7%). The overall response rate was 24.4% (two complete and eight partial). Six patients (14.6%) underwent definite pancreatic resection and four had negative surgical margins. The intention of the treatment analysis showed that the median survival time and median time to tumour progression were 16.7 and 8.9 months. The 1- and 2-year survival rates were 63.3 and 27.9%, respectively. Overall survival was significantly longer in the low baseline CA19-9 group and therapeutic responders. Toxicities were tolerable and successfully managed by conservative treatments. The therapeutic scheme of a weekly full dose of gemcitabine and a single dose of cisplatin combined with external radiation is effective and might prolong the survival of patients with locally advanced pancreatic cancer.

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Related in: MedlinePlus

Overall survival (A) and TTP (B) of the enrolled 41 patients.
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fig1: Overall survival (A) and TTP (B) of the enrolled 41 patients.

Mentions: The median survival time of the 41 enrolled patients was 16.7 months (95% CI: 10.4–23.1 months) (Figure 1A). The median OS of resected and unresected patients was 21.7 months (95% CI: 14.1–29.3 months) and 12.6 months (95% CI: 7.5–17.7 months), respectively (P=0.079). The 1- and 2-year cumulative survival rates were 63.3 and 27.9%, respectively. The median TTP was 8.9 months (95% CI: 7.0–10.7 months) (Figure 1B).


Weekly full-dose gemcitabine and single-dose cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer.

Hong SP, Park JY, Jeon TJ, Bang S, Park SW, Chung JB, Park MS, Seong J, Lee WJ, Song SY - Br. J. Cancer (2008)

Overall survival (A) and TTP (B) of the enrolled 41 patients.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2266862&req=5

fig1: Overall survival (A) and TTP (B) of the enrolled 41 patients.
Mentions: The median survival time of the 41 enrolled patients was 16.7 months (95% CI: 10.4–23.1 months) (Figure 1A). The median OS of resected and unresected patients was 21.7 months (95% CI: 14.1–29.3 months) and 12.6 months (95% CI: 7.5–17.7 months), respectively (P=0.079). The 1- and 2-year cumulative survival rates were 63.3 and 27.9%, respectively. The median TTP was 8.9 months (95% CI: 7.0–10.7 months) (Figure 1B).

Bottom Line: Overall survival was significantly longer in the low baseline CA19-9 group and therapeutic responders.Toxicities were tolerable and successfully managed by conservative treatments.The therapeutic scheme of a weekly full dose of gemcitabine and a single dose of cisplatin combined with external radiation is effective and might prolong the survival of patients with locally advanced pancreatic cancer.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
The aim of this study was to evaluate the efficacy and the toxicity of a full dose of gemcitabine and a single dose of cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer. Forty-one patients with locally advanced pancreatic cancer were enrolled. Patients received gemcitabine (1000 mg m(-2) on days 1, 8, 15, 29, and 36) and cisplatin (70 mg m(-2) on days 1 and 29) with concurrent radiotherapy (45 Gy in 25 fractions). Treatment was completed in 38 out of 41 patients (92.7%). The overall response rate was 24.4% (two complete and eight partial). Six patients (14.6%) underwent definite pancreatic resection and four had negative surgical margins. The intention of the treatment analysis showed that the median survival time and median time to tumour progression were 16.7 and 8.9 months. The 1- and 2-year survival rates were 63.3 and 27.9%, respectively. Overall survival was significantly longer in the low baseline CA19-9 group and therapeutic responders. Toxicities were tolerable and successfully managed by conservative treatments. The therapeutic scheme of a weekly full dose of gemcitabine and a single dose of cisplatin combined with external radiation is effective and might prolong the survival of patients with locally advanced pancreatic cancer.

Show MeSH
Related in: MedlinePlus