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Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer.

Sakamoto K, Ohno-Okumura E, Kato T, Watanabe M, Cook MJ - Met Based Drugs (2008)

Bottom Line: Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine reacted with dimethyl sulfate and monochloroacetic acid to produce their quaternized products and diethyl sulfate to produce the sulfo-substituted products.All quaternized and sulfo-substituted showed amphiphilic character.Identical peaks in cyclic voltammograms appeared for these products before and after quaternization.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Molecular Chemistry, College of Industrial Technology, Nihon University, 1-2-1 Izumi-cho, Narashino-shi, Chiba-ken 275-8575, Japan.

ABSTRACT
The phthalocyanine analogue containing nonperipheral long alkyl-substituted benzenoid rings and pyridine rings, zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine, was synthesized. Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine reacted with dimethyl sulfate and monochloroacetic acid to produce their quaternized products and diethyl sulfate to produce the sulfo-substituted products. All quaternized and sulfo-substituted showed amphiphilic character. Identical peaks in cyclic voltammograms appeared for these products before and after quaternization. During the evaluation of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine for its photodynamic therapy of cancer (PDT) efficacy by cancer cell culture, the light exposed dimethyl sulfate quaternized zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazines in IU-002 cells produce cell disruption that can be detected as a decrease in fluorescence.

No MeSH data available.


Related in: MedlinePlus

CVs of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine.
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fig3: CVs of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine.

Mentions: The respective products obtained were greenish-blue-coloredpowders of which the yieldswere 24, 21, and 25% for MCAA, DES, and DMS, respectively (see Figure 3). Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido)porphyrazine was dissolved in toluene, chloroform, pyridine, and methanol butnot in water. After reacting with quaternizing agents, the products were alsosoluble in water.


Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer.

Sakamoto K, Ohno-Okumura E, Kato T, Watanabe M, Cook MJ - Met Based Drugs (2008)

CVs of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2266814&req=5

fig3: CVs of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine.
Mentions: The respective products obtained were greenish-blue-coloredpowders of which the yieldswere 24, 21, and 25% for MCAA, DES, and DMS, respectively (see Figure 3). Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido)porphyrazine was dissolved in toluene, chloroform, pyridine, and methanol butnot in water. After reacting with quaternizing agents, the products were alsosoluble in water.

Bottom Line: Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine reacted with dimethyl sulfate and monochloroacetic acid to produce their quaternized products and diethyl sulfate to produce the sulfo-substituted products.All quaternized and sulfo-substituted showed amphiphilic character.Identical peaks in cyclic voltammograms appeared for these products before and after quaternization.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Molecular Chemistry, College of Industrial Technology, Nihon University, 1-2-1 Izumi-cho, Narashino-shi, Chiba-ken 275-8575, Japan.

ABSTRACT
The phthalocyanine analogue containing nonperipheral long alkyl-substituted benzenoid rings and pyridine rings, zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine, was synthesized. Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine reacted with dimethyl sulfate and monochloroacetic acid to produce their quaternized products and diethyl sulfate to produce the sulfo-substituted products. All quaternized and sulfo-substituted showed amphiphilic character. Identical peaks in cyclic voltammograms appeared for these products before and after quaternization. During the evaluation of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine for its photodynamic therapy of cancer (PDT) efficacy by cancer cell culture, the light exposed dimethyl sulfate quaternized zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazines in IU-002 cells produce cell disruption that can be detected as a decrease in fluorescence.

No MeSH data available.


Related in: MedlinePlus