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Cationic porphyrin induced a telomeric DNA to g-quadruplex form in water.

Murashima T, Sakiyama D, Miyoshi D, Kuriyama M, Yamada T, Miyazawa T, Sugimoto N - Bioinorg Chem Appl (2008)

Bottom Line: The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers.Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.

View Article: PubMed Central - PubMed

Affiliation: Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan.

ABSTRACT
The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.

No MeSH data available.


Related in: MedlinePlus

CD spectra of d(TG4T2G4T) (25 μM) with (red) or without (black) porphyrin 5 (75 μM) in buffer containing 100 mM KCl and 50 mM Tris-HCl (pH 7.5) (a) and in water (b) at 0°C.
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fig3: CD spectra of d(TG4T2G4T) (25 μM) with (red) or without (black) porphyrin 5 (75 μM) in buffer containing 100 mM KCl and 50 mM Tris-HCl (pH 7.5) (a) and in water (b) at 0°C.


Cationic porphyrin induced a telomeric DNA to g-quadruplex form in water.

Murashima T, Sakiyama D, Miyoshi D, Kuriyama M, Yamada T, Miyazawa T, Sugimoto N - Bioinorg Chem Appl (2008)

CD spectra of d(TG4T2G4T) (25 μM) with (red) or without (black) porphyrin 5 (75 μM) in buffer containing 100 mM KCl and 50 mM Tris-HCl (pH 7.5) (a) and in water (b) at 0°C.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2266808&req=5

fig3: CD spectra of d(TG4T2G4T) (25 μM) with (red) or without (black) porphyrin 5 (75 μM) in buffer containing 100 mM KCl and 50 mM Tris-HCl (pH 7.5) (a) and in water (b) at 0°C.
Bottom Line: The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers.Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.

View Article: PubMed Central - PubMed

Affiliation: Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan.

ABSTRACT
The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.

No MeSH data available.


Related in: MedlinePlus