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Cationic porphyrin induced a telomeric DNA to g-quadruplex form in water.

Murashima T, Sakiyama D, Miyoshi D, Kuriyama M, Yamada T, Miyazawa T, Sugimoto N - Bioinorg Chem Appl (2008)

Bottom Line: The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers.Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.

View Article: PubMed Central - PubMed

Affiliation: Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan.

ABSTRACT
The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.

No MeSH data available.


Synthesis of cation tethered porphyrin 5.
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Related In: Results  -  Collection


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fig1: Synthesis of cation tethered porphyrin 5.

Mentions: Asa G-quadruplex-inducing agent, a novel cationic porphyrin 5 was prepared according to Scheme 1. The molecule 5 was designed to bind to G-quadruplex bya stacking interaction between porphyrin ring and G-quartet plane, togetherwith electrostatic interaction between ammonium cations and DNA backbone. Inspite of a postulated low affinity for G-quadruplex that is due to the bulkysubstituents, porphyrin 5 isexpected to grab at the G-quadruplex with the corporation of π-stacking and electrostaticinteractions. All the reactions were conducted in the dark.


Cationic porphyrin induced a telomeric DNA to g-quadruplex form in water.

Murashima T, Sakiyama D, Miyoshi D, Kuriyama M, Yamada T, Miyazawa T, Sugimoto N - Bioinorg Chem Appl (2008)

Synthesis of cation tethered porphyrin 5.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2266808&req=5

fig1: Synthesis of cation tethered porphyrin 5.
Mentions: Asa G-quadruplex-inducing agent, a novel cationic porphyrin 5 was prepared according to Scheme 1. The molecule 5 was designed to bind to G-quadruplex bya stacking interaction between porphyrin ring and G-quartet plane, togetherwith electrostatic interaction between ammonium cations and DNA backbone. Inspite of a postulated low affinity for G-quadruplex that is due to the bulkysubstituents, porphyrin 5 isexpected to grab at the G-quadruplex with the corporation of π-stacking and electrostaticinteractions. All the reactions were conducted in the dark.

Bottom Line: The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers.Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.

View Article: PubMed Central - PubMed

Affiliation: Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan.

ABSTRACT
The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.

No MeSH data available.