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Dietary potassium supplementation improves vascular structure and ameliorates the damage caused by cerebral ischemia in normotensive rats.

Rigsby CS, Pollock DM, Dorrance AM - Nutr Metab (Lond) (2008)

Bottom Line: This protection includes a blood pressure independent reduction in the amount of damage caused by cerebral ischemia.Wall thickness and area were unchanged, suggesting an outward euthrophic remodelling process.The HK diet had no effect on body weight or telemetry blood pressure.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA. dorranc3@msu.edu.

ABSTRACT

Background: Dietary potassium supplementation in hypertensive rats is cardioprotective. This protection includes a blood pressure independent reduction in the amount of damage caused by cerebral ischemia. Therefore, we hypothesized that dietary potassium supplementation would improve the outcome of ischemic stroke by improving cerebral vessel structure in normotensive rats.

Methods: Wistar Kyoto (WKY) rats were fed a high (HK) or low potassium (LK) diet for six weeks from six weeks of age. At the end of treatment, cerebral ischemia was induced by middle cerebral artery (MCA) occlusion and the resultant infarct was quantified and expressed as a percentage of the hemisphere infarcted (%HI). MCA structure was assessed in an additional group of rats using a pressurized arteriograph.

Results: The cerebral infarct was significantly smaller in rats fed the HK diet, compared to rats fed the LK diet (21 +/- 5.4 vs 33.5 +/- 4.8 %HI HK vs LK p < 0.05). Vessel structure was improved in WKY rats fed the HK diet as indicated by an increase in the MCA lumen (298 +/- 6.3 vs 276 +/- 3.9 mum HK vs LK p < 0.05) and outer diameters (322 +/- 7.6 vs 305 +/- 4.8 mum HK vs LK p < 0.05). Wall thickness and area were unchanged, suggesting an outward euthrophic remodelling process. The HK diet had no effect on body weight or telemetry blood pressure.

Conclusion: These studies are the first to show a beneficial effect of dietary potassium in rats with normal blood pressure.

No MeSH data available.


Related in: MedlinePlus

Dietary potassium supplementation did not alter blood pressure in the WKY rats. Blood pressure was measured by telemetry and the average day and night blood pressures are shown (n = 3 in each group).
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Figure 1: Dietary potassium supplementation did not alter blood pressure in the WKY rats. Blood pressure was measured by telemetry and the average day and night blood pressures are shown (n = 3 in each group).

Mentions: Dietary potassium supplementation had no effect on the mean arterial blood pressure in the WKY rats (Figure 1). The rats from the two treatment groups had similar body weights (274 ± 4.5 vs 265 ± 5.4 grams HK vs LK). The plasma sodium levels were also similar between the two groups (142 ± 1.8 vs 144 ± 1.7 HK vs LK), there was a trend toward an increase in the plasma potassium levels in the rats fed the HK diet (5.2 ± 0.2 vs 4.9 ± 0.2 HK vs LK p = 0.25).


Dietary potassium supplementation improves vascular structure and ameliorates the damage caused by cerebral ischemia in normotensive rats.

Rigsby CS, Pollock DM, Dorrance AM - Nutr Metab (Lond) (2008)

Dietary potassium supplementation did not alter blood pressure in the WKY rats. Blood pressure was measured by telemetry and the average day and night blood pressures are shown (n = 3 in each group).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2266758&req=5

Figure 1: Dietary potassium supplementation did not alter blood pressure in the WKY rats. Blood pressure was measured by telemetry and the average day and night blood pressures are shown (n = 3 in each group).
Mentions: Dietary potassium supplementation had no effect on the mean arterial blood pressure in the WKY rats (Figure 1). The rats from the two treatment groups had similar body weights (274 ± 4.5 vs 265 ± 5.4 grams HK vs LK). The plasma sodium levels were also similar between the two groups (142 ± 1.8 vs 144 ± 1.7 HK vs LK), there was a trend toward an increase in the plasma potassium levels in the rats fed the HK diet (5.2 ± 0.2 vs 4.9 ± 0.2 HK vs LK p = 0.25).

Bottom Line: This protection includes a blood pressure independent reduction in the amount of damage caused by cerebral ischemia.Wall thickness and area were unchanged, suggesting an outward euthrophic remodelling process.The HK diet had no effect on body weight or telemetry blood pressure.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA. dorranc3@msu.edu.

ABSTRACT

Background: Dietary potassium supplementation in hypertensive rats is cardioprotective. This protection includes a blood pressure independent reduction in the amount of damage caused by cerebral ischemia. Therefore, we hypothesized that dietary potassium supplementation would improve the outcome of ischemic stroke by improving cerebral vessel structure in normotensive rats.

Methods: Wistar Kyoto (WKY) rats were fed a high (HK) or low potassium (LK) diet for six weeks from six weeks of age. At the end of treatment, cerebral ischemia was induced by middle cerebral artery (MCA) occlusion and the resultant infarct was quantified and expressed as a percentage of the hemisphere infarcted (%HI). MCA structure was assessed in an additional group of rats using a pressurized arteriograph.

Results: The cerebral infarct was significantly smaller in rats fed the HK diet, compared to rats fed the LK diet (21 +/- 5.4 vs 33.5 +/- 4.8 %HI HK vs LK p < 0.05). Vessel structure was improved in WKY rats fed the HK diet as indicated by an increase in the MCA lumen (298 +/- 6.3 vs 276 +/- 3.9 mum HK vs LK p < 0.05) and outer diameters (322 +/- 7.6 vs 305 +/- 4.8 mum HK vs LK p < 0.05). Wall thickness and area were unchanged, suggesting an outward euthrophic remodelling process. The HK diet had no effect on body weight or telemetry blood pressure.

Conclusion: These studies are the first to show a beneficial effect of dietary potassium in rats with normal blood pressure.

No MeSH data available.


Related in: MedlinePlus