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Thinner tubes

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A switch that controls cell intercalation determines the diameter of fly embryo tracheal tubes, according to Carlos Ribeiro, Marc Neumann, and Markus Affolter (Biozentrum, Universität Basel, Switzerland)... The Swiss team wanted to know what cellular processes were being controlled by Dpp and Wnt... This squeezing process continued until the tube was longer but only one cell circumference around... Expression of the Wnt target Spalt, a transcription factor, was necessary and sufficient to prevent this intercalation process in tubes that remained larger... Dpp's normal function, by contrast, is to repress Spalt expression and thus allow intercalation... Cells formed autocellular AJs as long as they had a Spalt-free neighbor... So perhaps it is contraction by the neighbor rather than outgrowth by the autocellular AJ-forming cell that is the driving force... Affolter plans to label old and new AJs to help him determine which cell is controlling the process and whether cell sliding, rolling, or detachment are involved in the reassortment of junctional contacts... Reference:

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Paired cells intercalate (top) as visualized via labeling of adherens junctions (bottom).AFFOLTER/ELSEVIER
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uro1: Paired cells intercalate (top) as visualized via labeling of adherens junctions (bottom).AFFOLTER/ELSEVIER


Thinner tubes
Paired cells intercalate (top) as visualized via labeling of adherens junctions (bottom).AFFOLTER/ELSEVIER
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2254705&req=5

uro1: Paired cells intercalate (top) as visualized via labeling of adherens junctions (bottom).AFFOLTER/ELSEVIER

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

A switch that controls cell intercalation determines the diameter of fly embryo tracheal tubes, according to Carlos Ribeiro, Marc Neumann, and Markus Affolter (Biozentrum, Universität Basel, Switzerland)... The Swiss team wanted to know what cellular processes were being controlled by Dpp and Wnt... This squeezing process continued until the tube was longer but only one cell circumference around... Expression of the Wnt target Spalt, a transcription factor, was necessary and sufficient to prevent this intercalation process in tubes that remained larger... Dpp's normal function, by contrast, is to repress Spalt expression and thus allow intercalation... Cells formed autocellular AJs as long as they had a Spalt-free neighbor... So perhaps it is contraction by the neighbor rather than outgrowth by the autocellular AJ-forming cell that is the driving force... Affolter plans to label old and new AJs to help him determine which cell is controlling the process and whether cell sliding, rolling, or detachment are involved in the reassortment of junctional contacts... Reference:

No MeSH data available.