Limits...
The Functions of PPARs in Aging and Longevity.

Erol A - PPAR Res (2007)

Bottom Line: Peroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress.PPARs are important redox-sensitive transcription factors and their dyregulated activations seem to be major culprits for these pathological processes.Drugs targeting PPARs activity are already in widespread clinical use; however, based on these concepts, this review highlights the understanding of the role of PPARs in aging and indicates the necessary particular attention for the potential therapeutic uses of current PPAR agonists in age-associated diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Faculty of Medicine, Celal Bayar University,45020 Manisa, Turkey.

ABSTRACT
Peroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress. A progressive rise of oxidative stress and related inflammatory reaction appears the hallmarks of the aging process and many age-related diseases. PPARs are important redox-sensitive transcription factors and their dyregulated activations seem to be major culprits for these pathological processes. Drugs targeting PPARs activity are already in widespread clinical use; however, based on these concepts, this review highlights the understanding of the role of PPARs in aging and indicates the necessary particular attention for the potential therapeutic uses of current PPAR agonists in age-associated diseases.

No MeSH data available.


Related in: MedlinePlus

In aging organism, two important sites regarding the energy metabolism, adipocytewith the increased lipogenesis, and skeletal muscle with the decreased fat oxidation are shown. Possible future therapeutic fields and expected beneficial alterations are also indicated.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2254525&req=5

fig2: In aging organism, two important sites regarding the energy metabolism, adipocytewith the increased lipogenesis, and skeletal muscle with the decreased fat oxidation are shown. Possible future therapeutic fields and expected beneficial alterations are also indicated.

Mentions: Reduction of PPARγ activity by small-molecule partial antagonists improves themetabolicprofile in mice. Although still at a preliminary stage, several compounds havebeenidentifiedthat may prove efficacious in the treatment of the metabolic syndrome and type2diabetes[50, 75]. One of these new generation compounds could prevent adipogenesis,insulin resistance, and obesity by blocking endogenous ligand-inducedactivation of PPARγ.In addition, these compounds may increase glucose disposal in peripheraltissues (see Figure 2) [76].


The Functions of PPARs in Aging and Longevity.

Erol A - PPAR Res (2007)

In aging organism, two important sites regarding the energy metabolism, adipocytewith the increased lipogenesis, and skeletal muscle with the decreased fat oxidation are shown. Possible future therapeutic fields and expected beneficial alterations are also indicated.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2254525&req=5

fig2: In aging organism, two important sites regarding the energy metabolism, adipocytewith the increased lipogenesis, and skeletal muscle with the decreased fat oxidation are shown. Possible future therapeutic fields and expected beneficial alterations are also indicated.
Mentions: Reduction of PPARγ activity by small-molecule partial antagonists improves themetabolicprofile in mice. Although still at a preliminary stage, several compounds havebeenidentifiedthat may prove efficacious in the treatment of the metabolic syndrome and type2diabetes[50, 75]. One of these new generation compounds could prevent adipogenesis,insulin resistance, and obesity by blocking endogenous ligand-inducedactivation of PPARγ.In addition, these compounds may increase glucose disposal in peripheraltissues (see Figure 2) [76].

Bottom Line: Peroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress.PPARs are important redox-sensitive transcription factors and their dyregulated activations seem to be major culprits for these pathological processes.Drugs targeting PPARs activity are already in widespread clinical use; however, based on these concepts, this review highlights the understanding of the role of PPARs in aging and indicates the necessary particular attention for the potential therapeutic uses of current PPAR agonists in age-associated diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Faculty of Medicine, Celal Bayar University,45020 Manisa, Turkey.

ABSTRACT
Peroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress. A progressive rise of oxidative stress and related inflammatory reaction appears the hallmarks of the aging process and many age-related diseases. PPARs are important redox-sensitive transcription factors and their dyregulated activations seem to be major culprits for these pathological processes. Drugs targeting PPARs activity are already in widespread clinical use; however, based on these concepts, this review highlights the understanding of the role of PPARs in aging and indicates the necessary particular attention for the potential therapeutic uses of current PPAR agonists in age-associated diseases.

No MeSH data available.


Related in: MedlinePlus