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A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient.

Miller MJ, Reuter BK, Wallace JL, Sharkey KA - J Transl Med (2008)

Bottom Line: These benefits were not associated with sedation or hypothermia and were not reversed by cannabinoid receptor antagonism.Zangrado did not exacerbate the ApcMincondition rather health was improved.Zangrado is an effective anti-emetic and anti-itch therapy that is devoid of common side-effects, cannabinoid-independent and broadly suppresses sensory afferent nerve activation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA. markjsm03@yahoo.com

ABSTRACT

Background: We examined the therapeutic potential of a proprietary Croton palanostigma extract (Zangrado(R)) in the management of emesis and itch.

Methods: Emesis was induced in ferrets with morphine-6-glucuronide (0.05 mg/kg sc) in the presence of Zangrado (3 mg/kg, ip) and the cannabinoid receptor 1 antagonist, AM 251 (5 mg/kg, ip). Topical Zangrado (1%) was assessed for anti-pruretic actions in the 5-HT-induced scratching model in rats and evaluated in capsaicin-induced gastric hyperemia as measured by laser doppler flow. In the ApcMinmouse model of precancerous adenomatosis polyposis, mice received Zangrado (100 mug/ml in drinking water) from the age of 6 - 16 weeks for effects on polyp number. In RAW 264.7 cells Zangrado was examined for effects on lipopolysaccharide-induced nitrite production.

Results: Zangrado was a highly effective anti-emetic, reducing morphine-induced vomiting and retching by 77%. These benefits were not associated with sedation or hypothermia and were not reversed by cannabinoid receptor antagonism. Itch responses were blocked in both the morphine and 5-HT models. Zangrado did not exacerbate the ApcMincondition rather health was improved. Capsaicin-induced hyperemia was blocked by Zangrado, which also attenuated the production of nitric oxide by activated macrophages.

Conclusion: Zangrado is an effective anti-emetic and anti-itch therapy that is devoid of common side-effects, cannabinoid-independent and broadly suppresses sensory afferent nerve activation. This complementary medicine represents a promising new approach to the management of nausea, itch and irritable bowel syndrome.

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Related in: MedlinePlus

Time course of the scratching response to subcutaneous 5-HT. Number of episodes of scratching in 5-min intervals over a one-hour period after injection of 5HT subcutaneously. (n = 5 per group) Controls got an injection of an identical volume of saline (100 μl).
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Figure 4: Time course of the scratching response to subcutaneous 5-HT. Number of episodes of scratching in 5-min intervals over a one-hour period after injection of 5HT subcutaneously. (n = 5 per group) Controls got an injection of an identical volume of saline (100 μl).

Mentions: Local administration of 5-HT evokes a scratching response at the site of the injection that peaks within 10 minutes and then slowly declines over the course of the 60 minute observation period (Figure 4). By contrast saline did not evoke a scratching response.


A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient.

Miller MJ, Reuter BK, Wallace JL, Sharkey KA - J Transl Med (2008)

Time course of the scratching response to subcutaneous 5-HT. Number of episodes of scratching in 5-min intervals over a one-hour period after injection of 5HT subcutaneously. (n = 5 per group) Controls got an injection of an identical volume of saline (100 μl).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2254379&req=5

Figure 4: Time course of the scratching response to subcutaneous 5-HT. Number of episodes of scratching in 5-min intervals over a one-hour period after injection of 5HT subcutaneously. (n = 5 per group) Controls got an injection of an identical volume of saline (100 μl).
Mentions: Local administration of 5-HT evokes a scratching response at the site of the injection that peaks within 10 minutes and then slowly declines over the course of the 60 minute observation period (Figure 4). By contrast saline did not evoke a scratching response.

Bottom Line: These benefits were not associated with sedation or hypothermia and were not reversed by cannabinoid receptor antagonism.Zangrado did not exacerbate the ApcMincondition rather health was improved.Zangrado is an effective anti-emetic and anti-itch therapy that is devoid of common side-effects, cannabinoid-independent and broadly suppresses sensory afferent nerve activation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA. markjsm03@yahoo.com

ABSTRACT

Background: We examined the therapeutic potential of a proprietary Croton palanostigma extract (Zangrado(R)) in the management of emesis and itch.

Methods: Emesis was induced in ferrets with morphine-6-glucuronide (0.05 mg/kg sc) in the presence of Zangrado (3 mg/kg, ip) and the cannabinoid receptor 1 antagonist, AM 251 (5 mg/kg, ip). Topical Zangrado (1%) was assessed for anti-pruretic actions in the 5-HT-induced scratching model in rats and evaluated in capsaicin-induced gastric hyperemia as measured by laser doppler flow. In the ApcMinmouse model of precancerous adenomatosis polyposis, mice received Zangrado (100 mug/ml in drinking water) from the age of 6 - 16 weeks for effects on polyp number. In RAW 264.7 cells Zangrado was examined for effects on lipopolysaccharide-induced nitrite production.

Results: Zangrado was a highly effective anti-emetic, reducing morphine-induced vomiting and retching by 77%. These benefits were not associated with sedation or hypothermia and were not reversed by cannabinoid receptor antagonism. Itch responses were blocked in both the morphine and 5-HT models. Zangrado did not exacerbate the ApcMincondition rather health was improved. Capsaicin-induced hyperemia was blocked by Zangrado, which also attenuated the production of nitric oxide by activated macrophages.

Conclusion: Zangrado is an effective anti-emetic and anti-itch therapy that is devoid of common side-effects, cannabinoid-independent and broadly suppresses sensory afferent nerve activation. This complementary medicine represents a promising new approach to the management of nausea, itch and irritable bowel syndrome.

Show MeSH
Related in: MedlinePlus