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Endomyocardial fibrosis: still a mystery after 60 years.

Bukhman G, Ziegler J, Parry E - PLoS Negl Trop Dis (2008)

Bottom Line: The pathologist Jack N.Since that time, reports of this restrictive cardiomyopathy have come from other parts of tropical Africa, South Asia, and South America.Despite several hypotheses regarding cause, no account of the etiology of this disease has yet fully explained its unique geographical distribution.

View Article: PubMed Central - PubMed

Affiliation: Division of Social Medicine and Health Inequalities, Brigham and Women's Hospital, Boston, Massachusetts, USA. gbukhman@partners.org

ABSTRACT
The pathologist Jack N. P. Davies identified endomyocardial fibrosis in Uganda in 1947. Since that time, reports of this restrictive cardiomyopathy have come from other parts of tropical Africa, South Asia, and South America. In Kampala, the disease accounts for 20% of heart disease patients referred for echocardiography. We conducted a systematic review of research on the epidemiology and etiology of endomyocardial fibrosis. We relied primarily on articles in the MEDLINE database with either "endomyocardial fibrosis" or "endomyocardial sclerosis" in the title. The volume of publications on endomyocardial fibrosis has declined since the 1980s. Despite several hypotheses regarding cause, no account of the etiology of this disease has yet fully explained its unique geographical distribution.

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Related in: MedlinePlus

Distribution by country of published cases of endomyocardial fibrosis between 1950 and 2006.Includes only those cases diagnosed at autopsy, or confirmed by surgery or cardiac imaging. Within-country variation depicted for Brazil, China, India, Mozambique, and Nigeria.
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pntd-0000097-g003: Distribution by country of published cases of endomyocardial fibrosis between 1950 and 2006.Includes only those cases diagnosed at autopsy, or confirmed by surgery or cardiac imaging. Within-country variation depicted for Brazil, China, India, Mozambique, and Nigeria.

Mentions: Since the first descriptions of EMF at autopsy in West and East Africans in the late 1940s, over 2,400 cases of the disease have been reported throughout the world [1],[29]. Half of these cases have come from sub-Saharan Africa, and a quarter have come from Uganda alone. Connor and colleagues have questioned the relationship between Ugandan EMF and the West African disease [3]. Other regions with large series include Brazil, Côte d'Ivoire, southern Nigeria, coastal Mozambique, and Kerala State in India (Figure 3). Reporting bias skews this distribution, and in the absence of population-based studies, worldwide prevalence can only be estimated.


Endomyocardial fibrosis: still a mystery after 60 years.

Bukhman G, Ziegler J, Parry E - PLoS Negl Trop Dis (2008)

Distribution by country of published cases of endomyocardial fibrosis between 1950 and 2006.Includes only those cases diagnosed at autopsy, or confirmed by surgery or cardiac imaging. Within-country variation depicted for Brazil, China, India, Mozambique, and Nigeria.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2254164&req=5

pntd-0000097-g003: Distribution by country of published cases of endomyocardial fibrosis between 1950 and 2006.Includes only those cases diagnosed at autopsy, or confirmed by surgery or cardiac imaging. Within-country variation depicted for Brazil, China, India, Mozambique, and Nigeria.
Mentions: Since the first descriptions of EMF at autopsy in West and East Africans in the late 1940s, over 2,400 cases of the disease have been reported throughout the world [1],[29]. Half of these cases have come from sub-Saharan Africa, and a quarter have come from Uganda alone. Connor and colleagues have questioned the relationship between Ugandan EMF and the West African disease [3]. Other regions with large series include Brazil, Côte d'Ivoire, southern Nigeria, coastal Mozambique, and Kerala State in India (Figure 3). Reporting bias skews this distribution, and in the absence of population-based studies, worldwide prevalence can only be estimated.

Bottom Line: The pathologist Jack N.Since that time, reports of this restrictive cardiomyopathy have come from other parts of tropical Africa, South Asia, and South America.Despite several hypotheses regarding cause, no account of the etiology of this disease has yet fully explained its unique geographical distribution.

View Article: PubMed Central - PubMed

Affiliation: Division of Social Medicine and Health Inequalities, Brigham and Women's Hospital, Boston, Massachusetts, USA. gbukhman@partners.org

ABSTRACT
The pathologist Jack N. P. Davies identified endomyocardial fibrosis in Uganda in 1947. Since that time, reports of this restrictive cardiomyopathy have come from other parts of tropical Africa, South Asia, and South America. In Kampala, the disease accounts for 20% of heart disease patients referred for echocardiography. We conducted a systematic review of research on the epidemiology and etiology of endomyocardial fibrosis. We relied primarily on articles in the MEDLINE database with either "endomyocardial fibrosis" or "endomyocardial sclerosis" in the title. The volume of publications on endomyocardial fibrosis has declined since the 1980s. Despite several hypotheses regarding cause, no account of the etiology of this disease has yet fully explained its unique geographical distribution.

Show MeSH
Related in: MedlinePlus