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Heart-shaped clones

View Article: PubMed Central

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The intricate shape of the heart is formed by oriented cell growth patterns, according to Meilhac et al. on page 97... For instance, in the outflow tract of the heart, which is a tubular region, the clones grew longitudinally along the long axis... In contrast, in the rounded ventricle, the clones were oriented like the spokes of an umbrella... A computer simulation revealed that similar clone shapes could be formed by simply restricting the plane of cell division... Thus, as long as daughter cells continue to divide along the original mitotic orientation, outside signaling among cardiac cells may not be necessary to attain the clonal shapes seen in vivo... It remains to be determined how each region of cells chooses its mitotic plane... Other mammalian organs, such as the brain or kidney, may also be shaped by oriented cell divison... Cruder shapes might be formed by variances in proliferation rates, but the group suggests that fine shaping is more easily accomplished by oriented cell division. ▪

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Cells in the future right ventricle grow in an oriented pattern resembling the final shape of the ventricle.
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uro1: Cells in the future right ventricle grow in an oriented pattern resembling the final shape of the ventricle.


Heart-shaped clones
Cells in the future right ventricle grow in an oriented pattern resembling the final shape of the ventricle.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2249869&req=5

uro1: Cells in the future right ventricle grow in an oriented pattern resembling the final shape of the ventricle.

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The intricate shape of the heart is formed by oriented cell growth patterns, according to Meilhac et al. on page 97... For instance, in the outflow tract of the heart, which is a tubular region, the clones grew longitudinally along the long axis... In contrast, in the rounded ventricle, the clones were oriented like the spokes of an umbrella... A computer simulation revealed that similar clone shapes could be formed by simply restricting the plane of cell division... Thus, as long as daughter cells continue to divide along the original mitotic orientation, outside signaling among cardiac cells may not be necessary to attain the clonal shapes seen in vivo... It remains to be determined how each region of cells chooses its mitotic plane... Other mammalian organs, such as the brain or kidney, may also be shaped by oriented cell divison... Cruder shapes might be formed by variances in proliferation rates, but the group suggests that fine shaping is more easily accomplished by oriented cell division. ▪

No MeSH data available.