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Evaluation of Antioxidant and Wound Healing Effects of Alcoholic and Aqueous Extract of Ocimum sanctum Linn in Rats.

Shetty S, Udupa S, Udupa L - Evid Based Complement Alternat Med (2008)

Bottom Line: Group 1 is normal wounded control and the other four groups were treated with two different doses each of alcoholic and aqueous extract of O. sanctum.Both the doses of alcoholic and aqueous extract significantly increased wound breaking strength, hydroxyproline, hexuronic acid, hexosamines, superoxide dismutase, catalase, reduced glutathione and significantly decreased percentage of wound contraction and lipid peroxidation when compared with the control group.The results suggest that O. sanctum has antioxidant properties, which may be responsible and favorable for faster wound healing and this plant extract may be useful in the management of abnormal healing and hypertropic scars.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Melaka Manipal Medical College, Department of Biochemistry, KMC International Centre and Department of Pharmacology, Kasturba Medical College, Manipal 576104, India.

ABSTRACT
In recent years, oxidative stress and free radicals have been implicated in impaired wound healing. Ocimum sanctum (O. sanctum), a plant widely used in Ayurveda, possesses anti-inflammatory and antioxidant properties. The present study was undertaken to assess the potential of alcoholic and aqueous extracts in wound healing in Wistar albino rats. The rats were divided into five groups of six animals each. Group 1 is normal wounded control and the other four groups were treated with two different doses each of alcoholic and aqueous extract of O. sanctum. The wound healing parameters were evaluated by using incision, excision and dead space wounds in extract-treated rats and controls. Both the doses of alcoholic and aqueous extract significantly increased wound breaking strength, hydroxyproline, hexuronic acid, hexosamines, superoxide dismutase, catalase, reduced glutathione and significantly decreased percentage of wound contraction and lipid peroxidation when compared with the control group. The results suggest that O. sanctum has antioxidant properties, which may be responsible and favorable for faster wound healing and this plant extract may be useful in the management of abnormal healing and hypertropic scars.

No MeSH data available.


Related in: MedlinePlus

Effect of aqueous and alcoholic extracts of O. sanctum on physical (WBS) and biochemical parameters.
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Figure 1: Effect of aqueous and alcoholic extracts of O. sanctum on physical (WBS) and biochemical parameters.

Mentions: In the incision wound model, WBS was measured. WBS was significantly increased in the O. sanctum-treated group compared with control with both the extracts and with both the doses. There was not much significant difference in WBS in the dose and type of extracts (Fig. 1A).Figure 1.


Evaluation of Antioxidant and Wound Healing Effects of Alcoholic and Aqueous Extract of Ocimum sanctum Linn in Rats.

Shetty S, Udupa S, Udupa L - Evid Based Complement Alternat Med (2008)

Effect of aqueous and alcoholic extracts of O. sanctum on physical (WBS) and biochemical parameters.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2249741&req=5

Figure 1: Effect of aqueous and alcoholic extracts of O. sanctum on physical (WBS) and biochemical parameters.
Mentions: In the incision wound model, WBS was measured. WBS was significantly increased in the O. sanctum-treated group compared with control with both the extracts and with both the doses. There was not much significant difference in WBS in the dose and type of extracts (Fig. 1A).Figure 1.

Bottom Line: Group 1 is normal wounded control and the other four groups were treated with two different doses each of alcoholic and aqueous extract of O. sanctum.Both the doses of alcoholic and aqueous extract significantly increased wound breaking strength, hydroxyproline, hexuronic acid, hexosamines, superoxide dismutase, catalase, reduced glutathione and significantly decreased percentage of wound contraction and lipid peroxidation when compared with the control group.The results suggest that O. sanctum has antioxidant properties, which may be responsible and favorable for faster wound healing and this plant extract may be useful in the management of abnormal healing and hypertropic scars.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Melaka Manipal Medical College, Department of Biochemistry, KMC International Centre and Department of Pharmacology, Kasturba Medical College, Manipal 576104, India.

ABSTRACT
In recent years, oxidative stress and free radicals have been implicated in impaired wound healing. Ocimum sanctum (O. sanctum), a plant widely used in Ayurveda, possesses anti-inflammatory and antioxidant properties. The present study was undertaken to assess the potential of alcoholic and aqueous extracts in wound healing in Wistar albino rats. The rats were divided into five groups of six animals each. Group 1 is normal wounded control and the other four groups were treated with two different doses each of alcoholic and aqueous extract of O. sanctum. The wound healing parameters were evaluated by using incision, excision and dead space wounds in extract-treated rats and controls. Both the doses of alcoholic and aqueous extract significantly increased wound breaking strength, hydroxyproline, hexuronic acid, hexosamines, superoxide dismutase, catalase, reduced glutathione and significantly decreased percentage of wound contraction and lipid peroxidation when compared with the control group. The results suggest that O. sanctum has antioxidant properties, which may be responsible and favorable for faster wound healing and this plant extract may be useful in the management of abnormal healing and hypertropic scars.

No MeSH data available.


Related in: MedlinePlus