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Green brazilian propolis action on macrophages and lymphoid organs of chronically stressed mice.

Missima F, Sforcin JM - Evid Based Complement Alternat Med (2008)

Bottom Line: Propolis immunomodulatory action has been mentioned and it has been the subject of scientific investigation in our laboratory.Histopathological analysis showed no alterations in the thymus, bone marrow and adrenal glands, but increased germinal centers in the spleen.New research is being carried out in order to elucidate propolis immunomodulatory action during stress.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618-000 Botucatu, S.P., Brazil.

ABSTRACT
Stress is a generic term that summarizes how psychosocial and environmental factors influence physical and mental well-being. The interaction between stress and immunity has been widely investigated, involving the neuroendocrine system and several organs. Assays using natural products in stress models deserve further investigation. Propolis immunomodulatory action has been mentioned and it has been the subject of scientific investigation in our laboratory. The aim of this study was to evaluate if and how propolis activated macrophages in BALB/c mice submitted to immobilization stress, as well as the histopathological analysis of the thymus, bone marrow, spleen and adrenal glands. Stressed mice showed a higher hydrogen peroxide (H(2)O(2)) generation by peritoneal macrophages, and propolis treatment potentiated H(2)O(2) generation and inhibited nitric oxide (NO) production by these cells. Histopathological analysis showed no alterations in the thymus, bone marrow and adrenal glands, but increased germinal centers in the spleen. Propolis treatment counteracted the alterations found in the spleen of stressed mice. New research is being carried out in order to elucidate propolis immunomodulatory action during stress.

No MeSH data available.


Propolis effect on NO generation by peritoneal macrophages of stressed mice. *significantly different from control (P < 0.01), **significantly different from propolis and propolis + stress (P < 0.01).
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Figure 2: Propolis effect on NO generation by peritoneal macrophages of stressed mice. *significantly different from control (P < 0.01), **significantly different from propolis and propolis + stress (P < 0.01).

Mentions: Stressed mice showed a reduced NO liberation as compared with control (P > 0.05) (Fig. 2). Propolis-treated mice showed an inhibition in NO production. Propolis administration to stressed mice also resulted in NO inhibition.Figure 2.


Green brazilian propolis action on macrophages and lymphoid organs of chronically stressed mice.

Missima F, Sforcin JM - Evid Based Complement Alternat Med (2008)

Propolis effect on NO generation by peritoneal macrophages of stressed mice. *significantly different from control (P < 0.01), **significantly different from propolis and propolis + stress (P < 0.01).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2249736&req=5

Figure 2: Propolis effect on NO generation by peritoneal macrophages of stressed mice. *significantly different from control (P < 0.01), **significantly different from propolis and propolis + stress (P < 0.01).
Mentions: Stressed mice showed a reduced NO liberation as compared with control (P > 0.05) (Fig. 2). Propolis-treated mice showed an inhibition in NO production. Propolis administration to stressed mice also resulted in NO inhibition.Figure 2.

Bottom Line: Propolis immunomodulatory action has been mentioned and it has been the subject of scientific investigation in our laboratory.Histopathological analysis showed no alterations in the thymus, bone marrow and adrenal glands, but increased germinal centers in the spleen.New research is being carried out in order to elucidate propolis immunomodulatory action during stress.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618-000 Botucatu, S.P., Brazil.

ABSTRACT
Stress is a generic term that summarizes how psychosocial and environmental factors influence physical and mental well-being. The interaction between stress and immunity has been widely investigated, involving the neuroendocrine system and several organs. Assays using natural products in stress models deserve further investigation. Propolis immunomodulatory action has been mentioned and it has been the subject of scientific investigation in our laboratory. The aim of this study was to evaluate if and how propolis activated macrophages in BALB/c mice submitted to immobilization stress, as well as the histopathological analysis of the thymus, bone marrow, spleen and adrenal glands. Stressed mice showed a higher hydrogen peroxide (H(2)O(2)) generation by peritoneal macrophages, and propolis treatment potentiated H(2)O(2) generation and inhibited nitric oxide (NO) production by these cells. Histopathological analysis showed no alterations in the thymus, bone marrow and adrenal glands, but increased germinal centers in the spleen. Propolis treatment counteracted the alterations found in the spleen of stressed mice. New research is being carried out in order to elucidate propolis immunomodulatory action during stress.

No MeSH data available.