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The cell cycle DB: a systems biology approach to cell cycle analysis.

Alfieri R, Merelli I, Mosca E, Milanesi L - Nucleic Acids Res. (2007)

Bottom Line: The cell cycle database is a biological resource that collects the most relevant information related to genes and proteins involved in human and yeast cell cycle processes.The database, which is accessible at the web site http://www.itb.cnr.it/cellcycle, has been developed in a systems biology context, since it also stores the cell cycle mathematical models published in the recent years, with the possibility to simulate them directly.The aim of our resource is to give an exhaustive view of the cell cycle process starting from its building-blocks, genes and proteins, toward the pathway they create, represented by the models.

View Article: PubMed Central - PubMed

Affiliation: Istituto di Tecnologie Biomediche-Consiglio Nazionale delle Ricerche, via F.lli Cervi 93, Segrate, Milano, Italy. roberta.alfieri@itb.cnr.it

ABSTRACT
The cell cycle database is a biological resource that collects the most relevant information related to genes and proteins involved in human and yeast cell cycle processes. The database, which is accessible at the web site http://www.itb.cnr.it/cellcycle, has been developed in a systems biology context, since it also stores the cell cycle mathematical models published in the recent years, with the possibility to simulate them directly. The aim of our resource is to give an exhaustive view of the cell cycle process starting from its building-blocks, genes and proteins, toward the pathway they create, represented by the models.

Show MeSH
Architecture of the Cell Cycle Database. The core of the resource is a data warehouse system which collects data from the most relevant bioinformatics resources (Data Sources) and provides links to external resources (Linked Resources). The Cell Cycle Database comprises user-friendly interfaces which show information and, in general, provide the functions of the resource, even relying on third party free software (SW).
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Figure 1: Architecture of the Cell Cycle Database. The core of the resource is a data warehouse system which collects data from the most relevant bioinformatics resources (Data Sources) and provides links to external resources (Linked Resources). The Cell Cycle Database comprises user-friendly interfaces which show information and, in general, provide the functions of the resource, even relying on third party free software (SW).

Mentions: In this biological context we developed the cell cycle database, a data integration system that collects information about genes, proteins and models of different organisms’ cell cycle network (Figure 1). We primary considered cell cycle information from humans since we intend to create a resource to support biomedical studies in the context of cancer research. Then we extended the database content toward the budding yeast cell cycle because of the large number of models available for this organism. According to this choice, the data integration concerns all genes and proteins involved in the cell cycle models of both the budding yeast Saccharomyces cerevisiae and the Homo sapiens. This information is taken from the most recent literature and plays a crucial role to contextualize behaviour of each cell cycle component.Figure 1.


The cell cycle DB: a systems biology approach to cell cycle analysis.

Alfieri R, Merelli I, Mosca E, Milanesi L - Nucleic Acids Res. (2007)

Architecture of the Cell Cycle Database. The core of the resource is a data warehouse system which collects data from the most relevant bioinformatics resources (Data Sources) and provides links to external resources (Linked Resources). The Cell Cycle Database comprises user-friendly interfaces which show information and, in general, provide the functions of the resource, even relying on third party free software (SW).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2238882&req=5

Figure 1: Architecture of the Cell Cycle Database. The core of the resource is a data warehouse system which collects data from the most relevant bioinformatics resources (Data Sources) and provides links to external resources (Linked Resources). The Cell Cycle Database comprises user-friendly interfaces which show information and, in general, provide the functions of the resource, even relying on third party free software (SW).
Mentions: In this biological context we developed the cell cycle database, a data integration system that collects information about genes, proteins and models of different organisms’ cell cycle network (Figure 1). We primary considered cell cycle information from humans since we intend to create a resource to support biomedical studies in the context of cancer research. Then we extended the database content toward the budding yeast cell cycle because of the large number of models available for this organism. According to this choice, the data integration concerns all genes and proteins involved in the cell cycle models of both the budding yeast Saccharomyces cerevisiae and the Homo sapiens. This information is taken from the most recent literature and plays a crucial role to contextualize behaviour of each cell cycle component.Figure 1.

Bottom Line: The cell cycle database is a biological resource that collects the most relevant information related to genes and proteins involved in human and yeast cell cycle processes.The database, which is accessible at the web site http://www.itb.cnr.it/cellcycle, has been developed in a systems biology context, since it also stores the cell cycle mathematical models published in the recent years, with the possibility to simulate them directly.The aim of our resource is to give an exhaustive view of the cell cycle process starting from its building-blocks, genes and proteins, toward the pathway they create, represented by the models.

View Article: PubMed Central - PubMed

Affiliation: Istituto di Tecnologie Biomediche-Consiglio Nazionale delle Ricerche, via F.lli Cervi 93, Segrate, Milano, Italy. roberta.alfieri@itb.cnr.it

ABSTRACT
The cell cycle database is a biological resource that collects the most relevant information related to genes and proteins involved in human and yeast cell cycle processes. The database, which is accessible at the web site http://www.itb.cnr.it/cellcycle, has been developed in a systems biology context, since it also stores the cell cycle mathematical models published in the recent years, with the possibility to simulate them directly. The aim of our resource is to give an exhaustive view of the cell cycle process starting from its building-blocks, genes and proteins, toward the pathway they create, represented by the models.

Show MeSH